caa a22 4500 605535485 CHVBK 20210128100847.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10517-015-2971-0 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2971-0 Molecular Factors of Cytokine-Dependent Activation of T Cells in Pulmonary Tuberculosis [Elektronische Daten] [I. Esimova, O. Urazova, M. Ignatova, V. Novitskii, Yu. Kolobovnikova] The parameters characterizing antituberculous immune response at the stage of cytokinedependent activation of T cells were analyzed in 90 patients with pulmonary tuberculosis before etiotropic therapy. Immunophenotyping of T cells for IL-12Rβ2, WSX-1, and gp130 surface markers and T-bet intracellular transcription factor was carried out after specific IL-12/IL-27 induction of cells in vitro. An increase in the counts of CD3+T-bet+, CD3+IL-12Rβ2 +, and CD3+WSX-1+gp130+ cells and the level of T cells with high expression of WSX-1 inhibitory molecule (CD3+WSX-1hi+gp130− and CD3+WSX-1hi+gp130+) was detected. The type of disorders in the inductive stage of antituberculous immune response did not depend on the clinical form of disease. Springer Science+Business Media New York, 2015 T cells nationallicence activation nationallicence interleukins nationallicence molecular mechanisms nationallicence pulmonary tuberculosis nationallicence Esimova I. Siberian State Medical University, Tomsk, Russia aut Urazova O. Siberian State Medical University, Tomsk, Russia aut Ignatova M. Siberian State Medical University, Tomsk, Russia aut Novitskii V. Siberian State Medical University, Tomsk, Russia aut Kolobovnikova Yu Siberian State Medical University, Tomsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 390-392 0007-4888 159:3<390 2015 159 10517 https://doi.org/10.1007/s10517-015-2971-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2971-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Esimova I. Siberian State Medical University, Tomsk, Russia aut NATIONALLICENCE 700 1- Urazova O. Siberian State Medical University, Tomsk, Russia aut NATIONALLICENCE 700 1- Ignatova M. Siberian State Medical University, Tomsk, Russia aut NATIONALLICENCE 700 1- Novitskii V. Siberian State Medical University, Tomsk, Russia aut NATIONALLICENCE 700 1- Kolobovnikova Yu Siberian State Medical University, Tomsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 390-392 0007-4888 159:3<390 2015 159 10517