Anti-Parkinsonian Activity of Hemantane on a Model of Hemiparkinsonian Syndrome in Rats
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 605535493 | ||
| 003 | CHVBK | ||
| 005 | 20210128100847.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20150701xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10517-015-2968-8 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2968-8 | ||
| 245 | 0 | 0 | |a Anti-Parkinsonian Activity of Hemantane on a Model of Hemiparkinsonian Syndrome in Rats |h [Elektronische Daten] |c [E. Ivanova, I. Kapitsa, E. Val'dman, T. Voronina] |
| 520 | 3 | |a Hemantane demonstrated a pronounced antiparkinsonian activity in the model of hemiparkinsonian syndrome provoked in rats by unilateral intracerebral injection of 6-hydroxydopamine, which was comparable to efficacy of levodopa in decreasing the duration of cataleptogenic state and the degree of akinesia of the contralesional forelimb assessed in the cylinder test. In the stepping test, hemantane exerted a long-term effect in contrast to levodopa, which diminished its beneficial action to the treatment day 21. In the swing test, the behavior normalized only by hemantane. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a hemiparkinsonism |2 nationallicence | |
| 690 | 7 | |a levodopa |2 nationallicence | |
| 690 | 7 | |a hemantane |2 nationallicence | |
| 690 | 7 | |a akinesia |2 nationallicence | |
| 690 | 7 | |a catalepsy |2 nationallicence | |
| 700 | 1 | |a Ivanova |D E. |u V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | |
| 700 | 1 | |a Kapitsa |D I. |u V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | |
| 700 | 1 | |a Val'dman |D E. |u V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | |
| 700 | 1 | |a Voronina |D T. |u V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/3(2015-07-01), 380-383 |x 0007-4888 |q 159:3<380 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2968-8 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2968-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ivanova |D E. |u V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kapitsa |D I. |u V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Val'dman |D E. |u V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Voronina |D T. |u V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/3(2015-07-01), 380-383 |x 0007-4888 |q 159:3<380 |1 2015 |2 159 |o 10517 | ||