caa a22 4500 605535493 CHVBK 20210128100847.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10517-015-2968-8 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2968-8 Anti-Parkinsonian Activity of Hemantane on a Model of Hemiparkinsonian Syndrome in Rats [Elektronische Daten] [E. Ivanova, I. Kapitsa, E. Val'dman, T. Voronina] Hemantane demonstrated a pronounced antiparkinsonian activity in the model of hemiparkinsonian syndrome provoked in rats by unilateral intracerebral injection of 6-hydroxydopamine, which was comparable to efficacy of levodopa in decreasing the duration of cataleptogenic state and the degree of akinesia of the contralesional forelimb assessed in the cylinder test. In the stepping test, hemantane exerted a long-term effect in contrast to levodopa, which diminished its beneficial action to the treatment day 21. In the swing test, the behavior normalized only by hemantane. Springer Science+Business Media New York, 2015 hemiparkinsonism nationallicence levodopa nationallicence hemantane nationallicence akinesia nationallicence catalepsy nationallicence Ivanova E. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut Kapitsa I. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut Val'dman E. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut Voronina T. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 380-383 0007-4888 159:3<380 2015 159 10517 https://doi.org/10.1007/s10517-015-2968-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2968-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ivanova E. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Kapitsa I. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Val'dman E. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Voronina T. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 380-383 0007-4888 159:3<380 2015 159 10517