caa a22 4500 605535523 CHVBK 20210128100848.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10517-015-2951-4 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2951-4 Expression of Neuropeptides, Neurotrophins, and Neurotransmitters in the Skin of Patients with Atopic Dermatitis and Psoriasis [Elektronische Daten] [A. Kubanov, O. Katunina, V. Chikin] Expression of neural marker PGP9.5, amphiregulin, semaphorin-3A, calcitonin gene-related peptide and its receptor, nerve growth factor and its receptor, substance P and its receptor, and expression frequency were analyzed in biopsy specimens from patients with atopic dermatitis and psoriasis and healthy volunteers by immunohistochemical method. Nerve fibers penetrated into the epidermis more frequently, and amphiregulin expression was significantly higher in patients with atopic dermatitis and psoriasis comparing to the control. Expression of semaphorin-3A in patients with atopic dermatitis was less frequent than in the control. These findings reflect the involvement of amphiregulin and semaphorin-3A in the improvement of skin innervations and penetration of nerve fibers into the epidermis, and due of which these proteins mediate the development of itch. Springer Science+Business Media New York, 2015 atopic dermatitis nationallicence psoriasis nationallicence itch nationallicence amphiregulin nationallicence semaphorin-3A nationallicence Kubanov A. State Research Center for Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia aut Katunina O. State Research Center for Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia aut Chikin V. State Research Center for Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 318-322 0007-4888 159:3<318 2015 159 10517 https://doi.org/10.1007/s10517-015-2951-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2951-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kubanov A. State Research Center for Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Katunina O. State Research Center for Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Chikin V. State Research Center for Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 318-322 0007-4888 159:3<318 2015 159 10517