Modifi cation of Anxious Behavior after Psychogenic Trauma and Treatment with Galanin Receptor Antagonist
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2958-x |2 doi |
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| 245 | 0 | 0 | |a Modifi cation of Anxious Behavior after Psychogenic Trauma and Treatment with Galanin Receptor Antagonist |h [Elektronische Daten] |c [V. Lyudyno, S. Tsikunov, I. Abdurasulova, A. Kusov, V. Klimenko] |
| 520 | 3 | |a Effects of blockage of central galanin receptors on anxiety manifestations were studied in rats with psychogenic trauma. Psychogenic trauma was modeled by exposure of a group of rats to the situation when the partner was killed by a predator. Antagonist of galanin receptors was intranasally administered before stress exposure. Animal behavior was evaluated using the elevated-plus maze test, free exploratory paradigm, and open-field test. Psychogenic trauma was followed by an increase in anxiety level and appearance of agitated behavior. Blockageof galanin receptors aggravated behavioral impairment, which manifested in the pathological anxious reactions - manifestations of hypervigilance and hyperawareness. The results suggest that endogenous pool of galanin is involved into prevention of excessive CNS response to stressful stimuli typical of posttraumatic stress disorder. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a psychogenic stress |2 nationallicence | |
| 690 | 7 | |a anxiety |2 nationallicence | |
| 690 | 7 | |a galanin |2 nationallicence | |
| 690 | 7 | |a posttraumatic stress disorder |2 nationallicence | |
| 700 | 1 | |a Lyudyno |D V. |u Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Tsikunov |D S. |u Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Abdurasulova |D I. |u Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Kusov |D A. |u Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Klimenko |D V. |u Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/3(2015-07-01), 344-347 |x 0007-4888 |q 159:3<344 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2958-x |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2958-x |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lyudyno |D V. |u Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tsikunov |D S. |u Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Abdurasulova |D I. |u Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kusov |D A. |u Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Klimenko |D V. |u Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/3(2015-07-01), 344-347 |x 0007-4888 |q 159:3<344 |1 2015 |2 159 |o 10517 | ||