caa a22 4500 60553554X CHVBK 20210128100848.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10517-015-2958-x doi (NATIONALLICENCE)springer-10.1007/s10517-015-2958-x Modifi cation of Anxious Behavior after Psychogenic Trauma and Treatment with Galanin Receptor Antagonist [Elektronische Daten] [V. Lyudyno, S. Tsikunov, I. Abdurasulova, A. Kusov, V. Klimenko] Effects of blockage of central galanin receptors on anxiety manifestations were studied in rats with psychogenic trauma. Psychogenic trauma was modeled by exposure of a group of rats to the situation when the partner was killed by a predator. Antagonist of galanin receptors was intranasally administered before stress exposure. Animal behavior was evaluated using the elevated-plus maze test, free exploratory paradigm, and open-field test. Psychogenic trauma was followed by an increase in anxiety level and appearance of agitated behavior. Blockageof galanin receptors aggravated behavioral impairment, which manifested in the pathological anxious reactions - manifestations of hypervigilance and hyperawareness. The results suggest that endogenous pool of galanin is involved into prevention of excessive CNS response to stressful stimuli typical of posttraumatic stress disorder. Springer Science+Business Media New York, 2015 psychogenic stress nationallicence anxiety nationallicence galanin nationallicence posttraumatic stress disorder nationallicence Lyudyno V. Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia aut Tsikunov S. Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia aut Abdurasulova I. Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia aut Kusov A. Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia aut Klimenko V. Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 344-347 0007-4888 159:3<344 2015 159 10517 https://doi.org/10.1007/s10517-015-2958-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2958-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lyudyno V. Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Tsikunov S. Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Abdurasulova I. Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Kusov A. Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Klimenko V. Research Institute of Experimental Medicine, the North-Western Division of Russian Academy of Medical sciences, St. Petersburg, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 344-347 0007-4888 159:3<344 2015 159 10517