caa a22 4500 605535566 CHVBK 20210128100848.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10517-015-2964-z doi (NATIONALLICENCE)springer-10.1007/s10517-015-2964-z Neuroprotective and Antioxidant Effects of Neuroglutam in Cerebral Ischemia [Elektronische Daten] [I. Tyurenkov, E. Volotova, D. Kurkin, N. Mazina, D. Bakulin, I. Logvinov, T. Antipova] We studied in vitro and in vivo neuroprotective and antioxidant properties of neuroglutam, a new glutamic acid derivative. In experiments on immortalized mouse hippocampal cell line HT22, neuroglutam exhibited a neuroprotective effect in the model of oxidative stress after its introduction, both before and after H2O2. In vivo study on animals treated with neuroglutam against the background of cerebral ischemia modeled by irreversible occlusion of the common carotid arteries showed that plasma level of TBA-active products was signifi cantly lower and activities of cell antioxidant enzymes (superoxide dismutase and catalase) were higher than in control animals receiving saline under the same conditions. Springer Science+Business Media New York, 2015 neuroprotective properties nationallicence antioxidant system nationallicence neuroglutam nationallicence Tyurenkov I. Volgograd State Medical University, Russian Ministry of Health, Volgograd, Russia aut Volotova E. Volgograd State Medical University, Russian Ministry of Health, Volgograd, Russia aut Kurkin D. Volgograd State Medical University, Russian Ministry of Health, Volgograd, Russia aut Mazina N. Volgograd State Medical University, Russian Ministry of Health, Volgograd, Russia aut Bakulin D. Volgograd State Medical University, Russian Ministry of Health, Volgograd, Russia aut Logvinov I. Volgograd State Medical University, Russian Ministry of Health, Volgograd, Russia aut Antipova T. V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 365-367 0007-4888 159:3<365 2015 159 10517 https://doi.org/10.1007/s10517-015-2964-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2964-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tyurenkov I. Volgograd State Medical University, Russian Ministry of Health, Volgograd, Russia aut NATIONALLICENCE 700 1- Volotova E. Volgograd State Medical University, Russian Ministry of Health, Volgograd, Russia aut NATIONALLICENCE 700 1- Kurkin D. Volgograd State Medical University, Russian Ministry of Health, Volgograd, Russia aut NATIONALLICENCE 700 1- Mazina N. Volgograd State Medical University, Russian Ministry of Health, Volgograd, Russia aut NATIONALLICENCE 700 1- Bakulin D. Volgograd State Medical University, Russian Ministry of Health, Volgograd, Russia aut NATIONALLICENCE 700 1- Logvinov I. Volgograd State Medical University, Russian Ministry of Health, Volgograd, Russia aut NATIONALLICENCE 700 1- Antipova T. V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 365-367 0007-4888 159:3<365 2015 159 10517