Depressive Behavior and Monoamine Contents in Brain Structures of Rats During Chronic Overcrowding
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2953-2 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2953-2 | ||
| 245 | 0 | 0 | |a Depressive Behavior and Monoamine Contents in Brain Structures of Rats During Chronic Overcrowding |h [Elektronische Daten] |c [E. Loseva, K. Sarkisova, N. Loginova, V. Kudrin] |
| 520 | 3 | |a Effects of chronic overcrowding on the development of depressive-like behavior and changes in monoamine contents in the brain structures involved in the development of depression were studied in rats. It was shown that overcrowding increased grooming duration and did not change the number of crossed squares and postures in the open-field test. In the forced swimming test, overcrowding increased immobility time and deceased the duration of the first episode of active swimming, which attested to depressive-like behavior. Overcrowding reduced the content of dopamine in the striatum, its metabolites (homovanilic and dioxyphenylacetic acids) and dopamine metabolism rate in the hypothalamus, and increased the concentrations of norepinephrine, homovanilic acid, and dioxyphenylacetic acid in the olfactory bulb and homovanilic acid in the prefrontal cortex. No changes were found in the nucleus accumbens. Serotonin content did not change in all analyzed structures. It was hypothesized that the observed changes in the content of monoamines and their metabolites in certain brain structures could underlie the depressive-like behavior induced by overcrowding in rats. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a depression |2 nationallicence | |
| 690 | 7 | |a overcrowding |2 nationallicence | |
| 690 | 7 | |a brain monoamines |2 nationallicence | |
| 690 | 7 | |a open-field test |2 nationallicence | |
| 690 | 7 | |a forced swimming test |2 nationallicence | |
| 700 | 1 | |a Loseva |D E. |u Research Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia |4 aut | |
| 700 | 1 | |a Sarkisova |D K. |u Research Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia |4 aut | |
| 700 | 1 | |a Loginova |D N. |u Research Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia |4 aut | |
| 700 | 1 | |a Kudrin |D V. |u V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/3(2015-07-01), 327-330 |x 0007-4888 |q 159:3<327 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2953-2 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2953-2 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Loseva |D E. |u Research Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sarkisova |D K. |u Research Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Loginova |D N. |u Research Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kudrin |D V. |u V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/3(2015-07-01), 327-330 |x 0007-4888 |q 159:3<327 |1 2015 |2 159 |o 10517 | ||