caa a22 4500 605535590 CHVBK 20210128100848.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10517-015-2953-2 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2953-2 Depressive Behavior and Monoamine Contents in Brain Structures of Rats During Chronic Overcrowding [Elektronische Daten] [E. Loseva, K. Sarkisova, N. Loginova, V. Kudrin] Effects of chronic overcrowding on the development of depressive-like behavior and changes in monoamine contents in the brain structures involved in the development of depression were studied in rats. It was shown that overcrowding increased grooming duration and did not change the number of crossed squares and postures in the open-field test. In the forced swimming test, overcrowding increased immobility time and deceased the duration of the first episode of active swimming, which attested to depressive-like behavior. Overcrowding reduced the content of dopamine in the striatum, its metabolites (homovanilic and dioxyphenylacetic acids) and dopamine metabolism rate in the hypothalamus, and increased the concentrations of norepinephrine, homovanilic acid, and dioxyphenylacetic acid in the olfactory bulb and homovanilic acid in the prefrontal cortex. No changes were found in the nucleus accumbens. Serotonin content did not change in all analyzed structures. It was hypothesized that the observed changes in the content of monoamines and their metabolites in certain brain structures could underlie the depressive-like behavior induced by overcrowding in rats. Springer Science+Business Media New York, 2015 depression nationallicence overcrowding nationallicence brain monoamines nationallicence open-field test nationallicence forced swimming test nationallicence Loseva E. Research Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia aut Sarkisova K. Research Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia aut Loginova N. Research Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia aut Kudrin V. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 327-330 0007-4888 159:3<327 2015 159 10517 https://doi.org/10.1007/s10517-015-2953-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2953-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Loseva E. Research Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Sarkisova K. Research Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Loginova N. Research Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Kudrin V. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 327-330 0007-4888 159:3<327 2015 159 10517