caa a22 4500 605535647 CHVBK 20210128100848.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10517-015-2945-2 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2945-2 Role of Adenohypophysotropic Neurohormones in Endocrine Paraadenohypophysial Regulation of Peripheral Target Organs in Rat Ontogeny [Elektronische Daten] [N. Bondarenko, Yu. Zubova, A. Sapronova, E. Volina, M. Ugrumov] We tested the hypothesis that brain-derived chemical stimuli contribute to direct endocrine regulation of peripheral organs during ontogeny before blood-brain barrier closure. Dopamine and gonadotropin-releasing hormone present in high concentration in peripheral blood only before blood-brain barrier closure were chosen as the chemical stimuli. It was shown than dopamine in concentrations equal to its level in the peripheral blood inhibits prolactin secretion in organotypic culture of the pituitary gland from newborn rats via specific receptors. Experiments on organotypic culture of neonatal rat testicles showed that gonadotropin-releasing hormone stimulates testosterone secretion via specific receptors. We proved that chemical stimuli entering common circulation from the brain before blood-brain barrier closure could exert direct endocrine effect on peripheral organs. Springer Science+Business Media New York, 2015 dopamine nationallicence gonadotropin-releasing hormone nationallicence organotypic culture nationallicence ontogeny nationallicence rat nationallicence Bondarenko N. N. K. Koltsov Institiute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia aut Zubova Yu N. K. Koltsov Institiute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia aut Sapronova A. N. K. Koltsov Institiute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia aut Volina E. N. K. Koltsov Institiute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia aut Ugrumov M. N. K. Koltsov Institiute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 293-296 0007-4888 159:3<293 2015 159 10517 https://doi.org/10.1007/s10517-015-2945-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2945-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bondarenko N. N. K. Koltsov Institiute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Zubova Yu N. K. Koltsov Institiute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Sapronova A. N. K. Koltsov Institiute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Volina E. N. K. Koltsov Institiute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Ugrumov M. N. K. Koltsov Institiute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 293-296 0007-4888 159:3<293 2015 159 10517