Factors of Suppression of Immune Response in Patients with Pulmonary Tuberculosis and Eosinophilia
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2952-3 |2 doi |
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| 245 | 0 | 0 | |a Factors of Suppression of Immune Response in Patients with Pulmonary Tuberculosis and Eosinophilia |h [Elektronische Daten] |c [O. Urazova, V. Novitskii, Yu. Kolobovnikova, E. Churina] |
| 520 | 3 | |a We studied possible mechanisms of immunosuppression mediated by regulatory T cells that promotes suppression of antigen-specific immune response to Mycobacterium tuberculosis in patients with pulmonary tuberculosis and eosinophilia. It was shown that the number of CD4+CD25+Foxp3+ regulatory T cells with immunosuppressive activity (Treg) increased in the peripheral blood of patients with disseminated destructive forms of pulmonary tuberculosis with multiple resistance of the causative agent to antituberculosis substances and eosinophilia. These changes were accompanied by imbalance in secretion of Treg-associated cytokines (in vitro) manifested in hyperproduction of TGFβ and IL-10 and decreased production of IL-2. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a regulatory T cells |2 nationallicence | |
| 690 | 7 | |a eosinophilia |2 nationallicence | |
| 690 | 7 | |a immunosuppression |2 nationallicence | |
| 690 | 7 | |a tuberculosis |2 nationallicence | |
| 700 | 1 | |a Urazova |D O. |u Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Novitskii |D V. |u Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Kolobovnikova |D Yu |u Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Churina |D E. |u Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/3(2015-07-01), 323-326 |x 0007-4888 |q 159:3<323 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2952-3 |q text/html |z Onlinezugriff via DOI |
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| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2952-3 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Urazova |D O. |u Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Novitskii |D V. |u Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kolobovnikova |D Yu |u Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Churina |D E. |u Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/3(2015-07-01), 323-326 |x 0007-4888 |q 159:3<323 |1 2015 |2 159 |o 10517 | ||