caa a22 4500 605535655 CHVBK 20210128100848.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10517-015-2952-3 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2952-3 Factors of Suppression of Immune Response in Patients with Pulmonary Tuberculosis and Eosinophilia [Elektronische Daten] [O. Urazova, V. Novitskii, Yu. Kolobovnikova, E. Churina] We studied possible mechanisms of immunosuppression mediated by regulatory T cells that promotes suppression of antigen-specific immune response to Mycobacterium tuberculosis in patients with pulmonary tuberculosis and eosinophilia. It was shown that the number of CD4+CD25+Foxp3+ regulatory T cells with immunosuppressive activity (Treg) increased in the peripheral blood of patients with disseminated destructive forms of pulmonary tuberculosis with multiple resistance of the causative agent to antituberculosis substances and eosinophilia. These changes were accompanied by imbalance in secretion of Treg-associated cytokines (in vitro) manifested in hyperproduction of TGFβ and IL-10 and decreased production of IL-2. Springer Science+Business Media New York, 2015 regulatory T cells nationallicence eosinophilia nationallicence immunosuppression nationallicence tuberculosis nationallicence Urazova O. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut Novitskii V. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut Kolobovnikova Yu Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut Churina E. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 323-326 0007-4888 159:3<323 2015 159 10517 https://doi.org/10.1007/s10517-015-2952-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2952-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Urazova O. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Novitskii V. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Kolobovnikova Yu Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Churina E. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 323-326 0007-4888 159:3<323 2015 159 10517