Effect of Pyrrolobenzimidazole Derivative RU-792 on Experimental Brain Ischemia
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2966-x |2 doi |
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| 245 | 0 | 0 | |a Effect of Pyrrolobenzimidazole Derivative RU-792 on Experimental Brain Ischemia |h [Elektronische Daten] |c [V. Kosolapov, D. Sorotskii, A. Spasov, V. Anisimova] |
| 520 | 3 | |a Compound RU-792 showed pronounced anti-ischemic activity and improved survival of rats with brain ischemia by normalizing parameters of spontaneous motor activity and reducing neurological deficit within 3 post-operative days being superior to the reference drug mexidol by this parameter. RU-792 inhibited the formation of conjugated dienes and malonic dialdehyde and increased activity of the antioxidant enzyme glutathione peroxidase thereby modulating the parameters of free radical oxidation in rats subjected to ischemia more effectively than mexidol. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a synthetic antioxidants |2 nationallicence | |
| 690 | 7 | |a free radical oxidation |2 nationallicence | |
| 690 | 7 | |a brain ischemia |2 nationallicence | |
| 700 | 1 | |a Kosolapov |D V. |u Department of Pharmacology, Rostov-on-Don, Russia |4 aut | |
| 700 | 1 | |a Sorotskii |D D. |u Laboratory of Pharmacology of Antioxidant Substances, Research Institute of Pharmacology, Volgograd State Medical Academy, Rostov-on-Don, Russia |4 aut | |
| 700 | 1 | |a Spasov |D A. |u Department of Pharmacology, Rostov-on-Don, Russia |4 aut | |
| 700 | 1 | |a Anisimova |D V. |u Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/3(2015-07-01), 372-375 |x 0007-4888 |q 159:3<372 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2966-x |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2966-x |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kosolapov |D V. |u Department of Pharmacology, Rostov-on-Don, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sorotskii |D D. |u Laboratory of Pharmacology of Antioxidant Substances, Research Institute of Pharmacology, Volgograd State Medical Academy, Rostov-on-Don, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Spasov |D A. |u Department of Pharmacology, Rostov-on-Don, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Anisimova |D V. |u Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/3(2015-07-01), 372-375 |x 0007-4888 |q 159:3<372 |1 2015 |2 159 |o 10517 | ||