caa a22 4500 605535663 CHVBK 20210128100848.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10517-015-2966-x doi (NATIONALLICENCE)springer-10.1007/s10517-015-2966-x Effect of Pyrrolobenzimidazole Derivative RU-792 on Experimental Brain Ischemia [Elektronische Daten] [V. Kosolapov, D. Sorotskii, A. Spasov, V. Anisimova] Compound RU-792 showed pronounced anti-ischemic activity and improved survival of rats with brain ischemia by normalizing parameters of spontaneous motor activity and reducing neurological deficit within 3 post-operative days being superior to the reference drug mexidol by this parameter. RU-792 inhibited the formation of conjugated dienes and malonic dialdehyde and increased activity of the antioxidant enzyme glutathione peroxidase thereby modulating the parameters of free radical oxidation in rats subjected to ischemia more effectively than mexidol. Springer Science+Business Media New York, 2015 synthetic antioxidants nationallicence free radical oxidation nationallicence brain ischemia nationallicence Kosolapov V. Department of Pharmacology, Rostov-on-Don, Russia aut Sorotskii D. Laboratory of Pharmacology of Antioxidant Substances, Research Institute of Pharmacology, Volgograd State Medical Academy, Rostov-on-Don, Russia aut Spasov A. Department of Pharmacology, Rostov-on-Don, Russia aut Anisimova V. Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 372-375 0007-4888 159:3<372 2015 159 10517 https://doi.org/10.1007/s10517-015-2966-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2966-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kosolapov V. Department of Pharmacology, Rostov-on-Don, Russia aut NATIONALLICENCE 700 1- Sorotskii D. Laboratory of Pharmacology of Antioxidant Substances, Research Institute of Pharmacology, Volgograd State Medical Academy, Rostov-on-Don, Russia aut NATIONALLICENCE 700 1- Spasov A. Department of Pharmacology, Rostov-on-Don, Russia aut NATIONALLICENCE 700 1- Anisimova V. Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 372-375 0007-4888 159:3<372 2015 159 10517