caa a22 4500 605535671 CHVBK 20210128100848.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10517-015-2956-z doi (NATIONALLICENCE)springer-10.1007/s10517-015-2956-z Differences in Active Avoidance Conditioning in Male and Female Rats with Experimental Anxiety-Depressive Disorder [Elektronische Daten] [N. Khlebnikova, N. Krupina, E. Kushnareva, I. Orlova] Using rat model of experimental anxiety-depressive disorder caused by postnatal administration of methionyl-2(S)-cyanopyrrolidine, an inhibitor of dipeptidyl peptidase IV, we compared conditioned active avoidance response and memory retention in males and females. In experimental males and females, conditioning was impaired in comparison with the control. In experimental groups, females were worse learners than males, while in control groups, females were better learners than males. Memory retention in experimental animals did not differ from that in controls 24 h after learning. Two months after learning, control females demonstrated better retention than control males. Springer Science+Business Media New York, 2015 model nationallicence anxiety-depressive disorder nationallicence conditioned active avoidance response nationallicence rat nationallicence Khlebnikova N. Laboratory of General Pathology of the Nervous System, Research Institute of General Pathology and Pathophysiology, Moscow, Russia aut Krupina N. Laboratory of General Pathology of the Nervous System, Research Institute of General Pathology and Pathophysiology, Moscow, Russia aut Kushnareva E. Laboratory of General Pathology of the Nervous System, Research Institute of General Pathology and Pathophysiology, Moscow, Russia aut Orlova I. Laboratory of General Pathology of the Nervous System, Research Institute of General Pathology and Pathophysiology, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 337-340 0007-4888 159:3<337 2015 159 10517 https://doi.org/10.1007/s10517-015-2956-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2956-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Khlebnikova N. Laboratory of General Pathology of the Nervous System, Research Institute of General Pathology and Pathophysiology, Moscow, Russia aut NATIONALLICENCE 700 1- Krupina N. Laboratory of General Pathology of the Nervous System, Research Institute of General Pathology and Pathophysiology, Moscow, Russia aut NATIONALLICENCE 700 1- Kushnareva E. Laboratory of General Pathology of the Nervous System, Research Institute of General Pathology and Pathophysiology, Moscow, Russia aut NATIONALLICENCE 700 1- Orlova I. Laboratory of General Pathology of the Nervous System, Research Institute of General Pathology and Pathophysiology, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 337-340 0007-4888 159:3<337 2015 159 10517