caa a22 4500 605535701 CHVBK 20210128100849.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10517-015-2989-3 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2989-3 Effectiveness of GK-2, a Nerve Growth Factor Mimetic, in Preventing Post-Resuscitation Changes in the Brain [Elektronische Daten] [Yu. Zarzhetskii, M. Avrushchenko, V. Moroz, T. Gudasheva, S. Seredenin] Neurological status was assessed and the numbers of neurons per 1 mm in pyramidal neuronal layer length in CA1 and CA4 hippocampal fi elds and cerebellar Purkinje cells were evaluated in albino male rats on post-resuscitation day 14 after 12-min cardiac arrest. Intraperitoneal administration of GK-2 (1 mg/kg 30 min after resuscitation and within the next 3 days with an interval of 24 h) accelerated neurological recovery of the animals, sharply reduced the intensity of cerebellar Purkinje cell death, and prevented loss of pyramidal neurons in the hippocampus. These results show the effectiveness of systemic administration of the nerve growth factor mimetic GK-2 in improving structural and functional state of the brain in the post-resuscitation period. This opens new prospects of its use for prevention and correction of post-hypoxic encephalopathy. Springer Science+Business Media New York, 2015 nerve growth factor mimetic GK-2 nationallicence post-resuscitation period nationallicence neuronal death nationallicence neurological recovery nationallicence Zarzhetskii Yu V. A. Negovsky Research Institute of General Resuscitation, Moscow, Russia aut Avrushchenko M. V. A. Negovsky Research Institute of General Resuscitation, Moscow, Russia aut Moroz V. V. A. Negovsky Research Institute of General Resuscitation, Moscow, Russia aut Gudasheva T. V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia aut Seredenin S. V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 453-455 0007-4888 159:4<453 2015 159 10517 https://doi.org/10.1007/s10517-015-2989-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2989-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zarzhetskii Yu V. A. Negovsky Research Institute of General Resuscitation, Moscow, Russia aut NATIONALLICENCE 700 1- Avrushchenko M. V. A. Negovsky Research Institute of General Resuscitation, Moscow, Russia aut NATIONALLICENCE 700 1- Moroz V. V. A. Negovsky Research Institute of General Resuscitation, Moscow, Russia aut NATIONALLICENCE 700 1- Gudasheva T. V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia aut NATIONALLICENCE 700 1- Seredenin S. V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 453-455 0007-4888 159:4<453 2015 159 10517