caa a22 4500 60553571X CHVBK 20210128100849.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10517-015-2999-1 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2999-1 Ratio of Active Matrix Metalloproteinases and Proenzymes during Growth and Metastasizing of Mouse Lewis Lung Adenocarcinoma [Elektronische Daten] [Ya. Kisarova, V. Kaledin, L. Bogdanova, T. Korolenko] Ratio between proMMP and active MMP was studied in the dynamics of growth of the Lewis lung adenocarcinoma with lung metastasis. It was shown that tumor growth is associated with an increase in the content of proMMP (day 20; terminal stage), but the level of active MMP in tumor tissue did not signifi cantly change. The development of lung metastasis was accompanied by accumulation of active MMP (days 7, 15, and 20) and a decrease in the content of pro-MMP (days 7, and 20) in comparison with the control. In the spleen of these mice (metastasis-free organ), an increase in the levels of proMMP (day 20) and especially active MMP (days 7, 15, and 20) were found. The results suggest that tumor development shifts the proportion between active MMP and proenzymes in the tumor, lungs with metastasis, and spleen without metastasis. Springer Science+Business Media New York, 2015 Lewis lung adenocarcinoma nationallicence lungs with metastasis nationallicence spleen nationallicence matrix metalloproteinases nationallicence proenzymes of matrix metalloproteinases nationallicence Kisarova Ya Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut Kaledin V. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Moscow, Russia aut Bogdanova L. Institute of Molecular Pathology and Pathomorphology, Vienna, Austria aut Korolenko T. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 486-489 0007-4888 159:4<486 2015 159 10517 https://doi.org/10.1007/s10517-015-2999-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2999-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kisarova Ya Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Kaledin V. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Moscow, Russia aut NATIONALLICENCE 700 1- Bogdanova L. Institute of Molecular Pathology and Pathomorphology, Vienna, Austria aut NATIONALLICENCE 700 1- Korolenko T. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 486-489 0007-4888 159:4<486 2015 159 10517