caa a22 4500 605535736 CHVBK 20210128100849.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10517-015-3010-x doi (NATIONALLICENCE)springer-10.1007/s10517-015-3010-x Effect of hrWnt7a on Human Retinal Pigment Epithelial Cells In Vitro [Elektronische Daten] [A. Kuznetsova, A. Kurinov, E. Chentsova, P. Makarov, M. Aleksandrova] Human recombinant protein Wnt7a (hrWnt7a) inhibits cell proliferative activity and triggers cell polarization. Although cell polarization process was maintained only over a short time, probably via microenvironmental stimuli, hrWnt7a is involved in the transformation of the retinal pigment epithelium. Analysis of Wnt signaling pathway and its regulation will help to understand the processes in retinal pigment epithelial cells under pathological conditions, which can be useful in developing new generation drugs. Springer Science+Business Media New York, 2015 human retinal pigment epithelium nationallicence cell culture nationallicence recombinant human protein Wnt7a nationallicence MTT test nationallicence immunohistochemistry nationallicence Kuznetsova A. N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut Kurinov A. N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut Chentsova E. Helmholtz Moscow Research Institute of Eye Diseases, Moscow, Russia aut Makarov P. Helmholtz Moscow Research Institute of Eye Diseases, Moscow, Russia aut Aleksandrova M. N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 534-540 0007-4888 159:4<534 2015 159 10517 https://doi.org/10.1007/s10517-015-3010-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3010-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kuznetsova A. N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Kurinov A. N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Chentsova E. Helmholtz Moscow Research Institute of Eye Diseases, Moscow, Russia aut NATIONALLICENCE 700 1- Makarov P. Helmholtz Moscow Research Institute of Eye Diseases, Moscow, Russia aut NATIONALLICENCE 700 1- Aleksandrova M. N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 534-540 0007-4888 159:4<534 2015 159 10517