caa a22 4500 605535752 CHVBK 20210128100849.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10517-015-2990-x doi (NATIONALLICENCE)springer-10.1007/s10517-015-2990-x Activity of Monoamine Oxidase in the Nigrostriatal System at Presymptomatic and Early Symptomatic Stages of Parkinsonism in Mice [Elektronische Daten] [G. Khakimova, E. Kozina, O. Buneeva, L. Aksenova, A. Medvedev, M. Ugryumov] Activities of monoamine oxidases A and B were examined on the models of presymptomatic and early symptomatic stages of Parkinson's disease developed in mice treated with MPTP, a specific neurotoxin affecting dopaminergic neurons. Activity of monoamine oxidases A, the key enzyme of dopamine degradation, is increased in neuronal somas during the symptomatic stage, and it is augmented in the axons during both stages. Neuronal activity of monoamine oxidases A is higher during the symptomatic stage than that during the presymptomatic stage, which can explain depletion of intercellular dopamine and appearance of motor disturbances. Activity of monoamine oxidase B in the striatum is reduced during the presymptomatic stage, but returns to the control level during the symptomatic stage. Variation in monoamine oxidase activity seems to reflect the compensatory mechanisms triggered in degrading nigrostriatal dopaminergic system. Springer Science+Business Media New York, 2015 monoamine oxidase nationallicence dopamine nationallicence mice nationallicence MPTP , Parkinson's disease nationallicence Khakimova G. N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut Kozina E. N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut Buneeva O. V. N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia aut Aksenova L. V. N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia aut Medvedev A. V. N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia aut Ugryumov M. N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 456-458 0007-4888 159:4<456 2015 159 10517 https://doi.org/10.1007/s10517-015-2990-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2990-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Khakimova G. N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Kozina E. N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Buneeva O. V. N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Aksenova L. V. N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Medvedev A. V. N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Ugryumov M. N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 456-458 0007-4888 159:4<456 2015 159 10517