caa a22 4500 605535760 CHVBK 20210128100849.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10517-015-2986-6 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2986-6 Proliferation, Migration, and Production of Nitric Oxide by Bone Marrow Multipotent Mesenchymal Stromal Cells from Wistar Rats in Hypoxia and Hyperglycemia [Elektronische Daten] [A. Lykov, Yu. Nikonorova, N. Bondarenko, O. Poveshchenko, I. Kim, A. Poveshchenko, V. Konenkov] We studied proliferation, migration, and secretion of NO by bone marrow multipotent mesenchymal stromal cells from Wistar rats during conditioning under hypoxic and hyperglycemic conditions and the effect of erythropoietin on these parameters. A stimulating effect of erythropoietin on cell proliferation under normal conditions and activation of cell proliferation under conditions of hypoxia and hyperglycemia were demonstrated. Erythropoietin abolishes suppression of cell proliferation in culture with normal glucose level under conditions of H2O2-induced hypoxia, while under conditions of hyperglycemia, inhibition of cell proliferation becomes more pronounced. Hypoxia promotes activation of cell migration along the growth factor concentration gradient and addition of erythropoietin to the nutrient medium leads to a decrease in cell migration activity. Erythropoietin stimulates NO production by cells cultured under the conditions of hypoxia and hyperglycemia. Springer Science+Business Media New York, 2015 multipotent mesenchymal stromal cells nationallicence oxidative stress nationallicence hyperglycemia nationallicence erythropoietin nationallicence proliferation nationallicence Lykov A. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia aut Nikonorova Yu Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia aut Bondarenko N. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia aut Poveshchenko O. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia aut Kim I. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia aut Poveshchenko A. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia aut Konenkov V. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 443-445 0007-4888 159:4<443 2015 159 10517 https://doi.org/10.1007/s10517-015-2986-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2986-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lykov A. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Nikonorova Yu Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Bondarenko N. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Poveshchenko O. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Kim I. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Poveshchenko A. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Konenkov V. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 443-445 0007-4888 159:4<443 2015 159 10517