caa a22 4500 605535787 CHVBK 20210128100849.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10517-015-2985-7 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2985-7 Characteristics of Lung Injury in Rats after Inhalation of Ultradisperse Bacterial LPS in Lipophilic and Hydrophilic Phases [Elektronische Daten] [V. Novochadov, D. Frolov, A. Shchyogolev] We compared cellular and tissue reactions of the lungs in Wistar rats after inhalation of LPS from E. coli 0128: B12 in the form of ultradispersion in water-salt phase and lipid phase. The estimated dose of the toxin was 200 mg/kg in both series. The content of LPS and TNF-α in lung homogenates, bronchoalveolar fluid, and blood serum was determined 3, 8, and 24 h after inhalation, morphological changes in the lungs were analyzed. Inhalation of LPS in the lipid phase was accompanied by its less intensive accumulation in the lung tissue and bloodstream, and more pronounced accumulation in the bronchoalveolar fluid as well as less intense release of TNF-α in comparison with the effects of LPS in water-salt phase. Macrophage reaction, leukocyte infiltration of the interalveolar septa, and reduction of α-antitrypsin in the lung tissue was more pronounced in series with inhalation with LPS ultradispersions in water-salt phase and lipid phase, and damage to the alveolar epithelium, in the series with the inhalation of the lipid phase. Springer Science+Business Media New York, 2015 lipopolysaccharide nationallicence inhalation intake nationallicence lungs nationallicence morphology nationallicence TNF-α nationallicence Novochadov V. Volgograd State University, Volgograd, Russia aut Frolov D. Volgograd State University, Volgograd, Russia aut Shchyogolev A. V. I. Kulakov Research Centre of Obstetrics, Gynecology and Perinatology, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 438-442 0007-4888 159:4<438 2015 159 10517 https://doi.org/10.1007/s10517-015-2985-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2985-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Novochadov V. Volgograd State University, Volgograd, Russia aut NATIONALLICENCE 700 1- Frolov D. Volgograd State University, Volgograd, Russia aut NATIONALLICENCE 700 1- Shchyogolev A. V. I. Kulakov Research Centre of Obstetrics, Gynecology and Perinatology, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 438-442 0007-4888 159:4<438 2015 159 10517