caa a22 4500 605535809 CHVBK 20210128100849.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10517-015-2988-4 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2988-4 Effect of Hypoxic Preconditioning on Stress Reaction in Rats [Elektronische Daten] [N. Naryzhnaya, L. Maslov, E. Vychuzhanova, A. Sementsov, Yu. Podoksyonov, A. Portnichenko, Yu. Lishmanov] In rats, immobilization stress (24 h) induced involution of the thymus and spleen, adrenal hypertrophy, and pronounced elevation (by 67%) of serum cortisol in comparison with intact animals; the mean number of stomach ulcers in rats subjected to stress was 6.9. Hypoxic preconditioning consisting of 6 sessions of 10-min hypoxia (8% O2) followed by 10-min reoxygenation with atmospheric air induced adrenal hypertrophy and spleen involution, but did not change blood cortisol level; no stomach ulcers were found in preconditioned rats. In rats subjected to both hypoxic preconditioning and immobilization, the weights of the thymus, adrenal glands, and spleen, as well as cortisol level did not differ from the corresponding parameters in rats subjected to immobilization stress alone. The number of stomach ulcers in experimental rats was 1.5-fold lower than in the stress-control ones. Thus, hypoxic preconditioning exerts a pronounced preventive anti-ulcer effect during immobilization, but it does not affect other indices of the stress reaction. Springer Science+Business Media New York, 2015 hypoxic preconditioning nationallicence stress nationallicence cross-adaptation nationallicence Naryzhnaya N. Research Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Maslov L. Research Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Vychuzhanova E. Research Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Sementsov A. Research Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Podoksyonov Yu Research Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Portnichenko A. Research Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Lishmanov Yu Research Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 450-452 0007-4888 159:4<450 2015 159 10517 https://doi.org/10.1007/s10517-015-2988-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2988-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Naryzhnaya N. Research Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Maslov L. Research Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Vychuzhanova E. Research Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Sementsov A. Research Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Podoksyonov Yu Research Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Portnichenko A. Research Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Lishmanov Yu Research Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 450-452 0007-4888 159:4<450 2015 159 10517