Experimental Study of the Mechanisms of Intracellular Defense in Cardiomyocytes Associated with Stages of Anthracosilicosis Development
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2983-9 |2 doi |
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| 245 | 0 | 0 | |a Experimental Study of the Mechanisms of Intracellular Defense in Cardiomyocytes Associated with Stages of Anthracosilicosis Development |h [Elektronische Daten] |c [V. Zakharenkov, N. Mikhailova, N. Zhdanova, L. Gorokhova, A. Zhukova] |
| 520 | 3 | |a Mechanisms of intracellular defense of rat cardiomyocytes were studied in dynamics of anthracosilicosis development induced by long-term inhalation of coal and rock dust. It was shown that synthesis of transcription factor HIF-1α and protective proteins increased in the heart at the early stages of coal and rock dust inhalation (1-3 weeks), and these changes limited the development of free radical oxidation and activated metabolism of glucose and fatty acids. Exposure to coal and rock dust for 6-12 weeks activated free radical oxidation and decreased basal metabolism in cardiomyocytes. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a anthracosilicosis |2 nationallicence | |
| 690 | 7 | |a myocardium |2 nationallicence | |
| 690 | 7 | |a HSP family proteins |2 nationallicence | |
| 690 | 7 | |a HIF-1α |2 nationallicence | |
| 690 | 7 | |a free radical oxidation |2 nationallicence | |
| 700 | 1 | |a Zakharenkov |D V. |u Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia |4 aut | |
| 700 | 1 | |a Mikhailova |D N. |u Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia |4 aut | |
| 700 | 1 | |a Zhdanova |D N. |u Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia |4 aut | |
| 700 | 1 | |a Gorokhova |D L. |u Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia |4 aut | |
| 700 | 1 | |a Zhukova |D A. |u Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/4(2015-08-01), 431-434 |x 0007-4888 |q 159:4<431 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2983-9 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2983-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zakharenkov |D V. |u Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mikhailova |D N. |u Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhdanova |D N. |u Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gorokhova |D L. |u Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhukova |D A. |u Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/4(2015-08-01), 431-434 |x 0007-4888 |q 159:4<431 |1 2015 |2 159 |o 10517 | ||