caa a22 4500 605535884 CHVBK 20210128100849.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10517-015-2983-9 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2983-9 Experimental Study of the Mechanisms of Intracellular Defense in Cardiomyocytes Associated with Stages of Anthracosilicosis Development [Elektronische Daten] [V. Zakharenkov, N. Mikhailova, N. Zhdanova, L. Gorokhova, A. Zhukova] Mechanisms of intracellular defense of rat cardiomyocytes were studied in dynamics of anthracosilicosis development induced by long-term inhalation of coal and rock dust. It was shown that synthesis of transcription factor HIF-1α and protective proteins increased in the heart at the early stages of coal and rock dust inhalation (1-3 weeks), and these changes limited the development of free radical oxidation and activated metabolism of glucose and fatty acids. Exposure to coal and rock dust for 6-12 weeks activated free radical oxidation and decreased basal metabolism in cardiomyocytes. Springer Science+Business Media New York, 2015 anthracosilicosis nationallicence myocardium nationallicence HSP family proteins nationallicence HIF-1α nationallicence free radical oxidation nationallicence Zakharenkov V. Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia aut Mikhailova N. Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia aut Zhdanova N. Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia aut Gorokhova L. Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia aut Zhukova A. Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 431-434 0007-4888 159:4<431 2015 159 10517 https://doi.org/10.1007/s10517-015-2983-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2983-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zakharenkov V. Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia aut NATIONALLICENCE 700 1- Mikhailova N. Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia aut NATIONALLICENCE 700 1- Zhdanova N. Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia aut NATIONALLICENCE 700 1- Gorokhova L. Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia aut NATIONALLICENCE 700 1- Zhukova A. Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 431-434 0007-4888 159:4<431 2015 159 10517