Effects of Glyprolines on DNA Synthesis and Free Radical Oxidation in Mouse Gastric Mucosa Under Physiological Conditions and During Therapy with Oral Non-Steroid Anti-Inflammatory Drugs
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3003-9 |2 doi |
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| 245 | 0 | 0 | |a Effects of Glyprolines on DNA Synthesis and Free Radical Oxidation in Mouse Gastric Mucosa Under Physiological Conditions and During Therapy with Oral Non-Steroid Anti-Inflammatory Drugs |h [Elektronische Daten] |c [M. Fleishman, I. Tolstenok, O. Lebed'ko, L. Andreeva, N. Myasoedov, S. Timoshin] |
| 520 | 3 | |a Studies by 3H-thymidin autoradiography showed that injections of Pro-Gly-Pro and Arg-Gly-Pro peptides caused no changes in the DNA synthesis processes in the gastric mucosa. Both peptides induced a reduction of free radical oxidation activity, which was shown by chemiluminescence. Indomethacin induced lesions in the gastric mucosa, triggered oxidative stress, and reduced proliferative activity. Injection of Pro-Gly-Pro peptide before indomethacin corrected disorders in oxidative status and normalized DNA synthesis. Preinjection of Arg-Gly-Pro led to enlargement (by 4.6 times) of the focus of lesions in animals treated by indomethacin and augmented oxidative stress. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a glyprolines |2 nationallicence | |
| 690 | 7 | |a NSAID-induced gastropathy |2 nationallicence | |
| 690 | 7 | |a DNA synthesis |2 nationallicence | |
| 690 | 7 | |a free radical oxidation |2 nationallicence | |
| 700 | 1 | |a Fleishman |D M. |u Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk, Russia |4 aut | |
| 700 | 1 | |a Tolstenok |D I. |u Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk, Russia |4 aut | |
| 700 | 1 | |a Lebed'ko |D O. |u Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk, Russia |4 aut | |
| 700 | 1 | |a Andreeva |D L. |u Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia |4 aut | |
| 700 | 1 | |a Myasoedov |D N. |u Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia |4 aut | |
| 700 | 1 | |a Timoshin |D S. |u Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/4(2015-08-01), 502-504 |x 0007-4888 |q 159:4<502 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3003-9 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3003-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fleishman |D M. |u Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tolstenok |D I. |u Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lebed'ko |D O. |u Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Andreeva |D L. |u Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Myasoedov |D N. |u Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Timoshin |D S. |u Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/4(2015-08-01), 502-504 |x 0007-4888 |q 159:4<502 |1 2015 |2 159 |o 10517 | ||