The Use of Autologous Mesenchymal Stem Cells for Cell Therapy of Patients with Amyotrophic Lateral Sclerosis in Belarus

Verfasser / Beitragende:
[Yu. Rushkevich, S. Kosmacheva, G. Zabrodets, S. Ignatenko, N. Goncharova, I. Severin, S. Likhachev, M. Potapnev]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 159/4(2015-08-01), 576-581
Format:
Artikel (online)
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024 7 0 |a 10.1007/s10517-015-3017-3  |2 doi 
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245 0 4 |a The Use of Autologous Mesenchymal Stem Cells for Cell Therapy of Patients with Amyotrophic Lateral Sclerosis in Belarus  |h [Elektronische Daten]  |c [Yu. Rushkevich, S. Kosmacheva, G. Zabrodets, S. Ignatenko, N. Goncharova, I. Severin, S. Likhachev, M. Potapnev] 
520 3 |a We studied a new method of treatment of amyotrophic lateral sclerosis with autologous mesenchymal stem cells. Autologous mesenchymal stem cells were injected intravenously (intact cells) or via lumbar puncture (cells committed to neuronal differentiation). Evaluation of the results of cell therapy after 12-month follow-up revealed slowing down of the disease progression in 10 patients in comparison with the control group consisting of 15 patients. The cell therapy was safe for the patients. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a amyotrophic lateral sclerosis  |2 nationallicence 
690 7 |a autologous mesenchymal stem cells  |2 nationallicence 
690 7 |a neurogenic differentiation  |2 nationallicence 
690 7 |a ALSFRS-R  |2 nationallicence 
690 7 |a Karnofsky scale  |2 nationallicence 
700 1 |a Rushkevich  |D Yu  |u Republican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, Belarus  |4 aut 
700 1 |a Kosmacheva  |D S.  |u Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus  |4 aut 
700 1 |a Zabrodets  |D G.  |u Republican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, Belarus  |4 aut 
700 1 |a Ignatenko  |D S.  |u Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus  |4 aut 
700 1 |a Goncharova  |D N.  |u Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus  |4 aut 
700 1 |a Severin  |D I.  |u Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus  |4 aut 
700 1 |a Likhachev  |D S.  |u Republican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, Belarus  |4 aut 
700 1 |a Potapnev  |D M.  |u Belorussian State Medical University, Minsk, Belarus  |4 aut 
773 0 |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/4(2015-08-01), 576-581  |x 0007-4888  |q 159:4<576  |1 2015  |2 159  |o 10517 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Rushkevich  |D Yu  |u Republican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, Belarus  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Kosmacheva  |D S.  |u Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Zabrodets  |D G.  |u Republican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, Belarus  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Ignatenko  |D S.  |u Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Goncharova  |D N.  |u Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Severin  |D I.  |u Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Likhachev  |D S.  |u Republican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, Belarus  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Potapnev  |D M.  |u Belorussian State Medical University, Minsk, Belarus  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/4(2015-08-01), 576-581  |x 0007-4888  |q 159:4<576  |1 2015  |2 159  |o 10517