caa a22 4500 605535922 CHVBK 20210128100850.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10517-015-3017-3 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3017-3 The Use of Autologous Mesenchymal Stem Cells for Cell Therapy of Patients with Amyotrophic Lateral Sclerosis in Belarus [Elektronische Daten] [Yu. Rushkevich, S. Kosmacheva, G. Zabrodets, S. Ignatenko, N. Goncharova, I. Severin, S. Likhachev, M. Potapnev] We studied a new method of treatment of amyotrophic lateral sclerosis with autologous mesenchymal stem cells. Autologous mesenchymal stem cells were injected intravenously (intact cells) or via lumbar puncture (cells committed to neuronal differentiation). Evaluation of the results of cell therapy after 12-month follow-up revealed slowing down of the disease progression in 10 patients in comparison with the control group consisting of 15 patients. The cell therapy was safe for the patients. Springer Science+Business Media New York, 2015 amyotrophic lateral sclerosis nationallicence autologous mesenchymal stem cells nationallicence neurogenic differentiation nationallicence ALSFRS-R nationallicence Karnofsky scale nationallicence Rushkevich Yu Republican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, Belarus aut Kosmacheva S. Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus aut Zabrodets G. Republican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, Belarus aut Ignatenko S. Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus aut Goncharova N. Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus aut Severin I. Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus aut Likhachev S. Republican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, Belarus aut Potapnev M. Belorussian State Medical University, Minsk, Belarus aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 576-581 0007-4888 159:4<576 2015 159 10517 https://doi.org/10.1007/s10517-015-3017-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3017-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rushkevich Yu Republican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, Belarus aut NATIONALLICENCE 700 1- Kosmacheva S. Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus aut NATIONALLICENCE 700 1- Zabrodets G. Republican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, Belarus aut NATIONALLICENCE 700 1- Ignatenko S. Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus aut NATIONALLICENCE 700 1- Goncharova N. Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus aut NATIONALLICENCE 700 1- Severin I. Republican Research-and-Practical Center of Transfusion and Medical Biotechnologies, Minsk, Belarus aut NATIONALLICENCE 700 1- Likhachev S. Republican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, Belarus aut NATIONALLICENCE 700 1- Potapnev M. Belorussian State Medical University, Minsk, Belarus aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 576-581 0007-4888 159:4<576 2015 159 10517