Morphological Changes in Rat Uterine Tissues and Possibility of Spontaneous Labor as a Result of Injection of Multipotent Mesenchymal Stromal Cells against the Background of Hydrometra

Verfasser / Beitragende:
[I. Maiborodin, N. Onoprienko, G. Chastikin]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 159/4(2015-08-01), 511-516
Format:
Artikel (online)
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024 7 0 |a 10.1007/s10517-015-3005-7  |2 doi 
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245 0 0 |a Morphological Changes in Rat Uterine Tissues and Possibility of Spontaneous Labor as a Result of Injection of Multipotent Mesenchymal Stromal Cells against the Background of Hydrometra  |h [Elektronische Daten]  |c [I. Maiborodin, N. Onoprienko, G. Chastikin] 
520 3 |a The possibility of pregnancy and labor was evaluated and tissue changes after injection of autologous bone marrow multipotent mesenchymal stromal cells with transfected GFP gene were studied in rats with experimental hydrometra. Injection of stromal cells to the uterine cicatrix increased the number of vessels (vascular walls or their elements) formed de novo with participation of injected cells. The animals produced progeny 2 estrous cycles earlier, the percentage of "puerperal” rats in this group was higher, their progeny was more numerous and they had the maximum numbers of little rats. The maternal mortality was lower after injection of stromal cells. Injection of stromal cells led to development of a trend to more rapid reparative processes in the uterus in animals with cicatricial stenosis of its lumen. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a uterine cicatrix  |2 nationallicence 
690 7 |a hydrometra  |2 nationallicence 
690 7 |a autologous bone marrow multipotent mesenchymal stromal cells  |2 nationallicence 
690 7 |a angiogenesis  |2 nationallicence 
700 1 |a Maiborodin  |D I.  |u Center of New Medical Technologies, Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia  |4 aut 
700 1 |a Onoprienko  |D N.  |u Center of New Medical Technologies, Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia  |4 aut 
700 1 |a Chastikin  |D G.  |u Center of New Medical Technologies, Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia  |4 aut 
773 0 |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/4(2015-08-01), 511-516  |x 0007-4888  |q 159:4<511  |1 2015  |2 159  |o 10517 
856 4 0 |u https://doi.org/10.1007/s10517-015-3005-7  |q text/html  |z Onlinezugriff via DOI 
898 |a BK010053  |b XK010053  |c XK010000 
900 7 |a Metadata rights reserved  |b Springer special CC-BY-NC licence  |2 nationallicence 
908 |D 1  |a research-article  |2 jats 
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950 |B NATIONALLICENCE  |P 856  |E 40  |u https://doi.org/10.1007/s10517-015-3005-7  |q text/html  |z Onlinezugriff via DOI 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Maiborodin  |D I.  |u Center of New Medical Technologies, Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Onoprienko  |D N.  |u Center of New Medical Technologies, Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Chastikin  |D G.  |u Center of New Medical Technologies, Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/4(2015-08-01), 511-516  |x 0007-4888  |q 159:4<511  |1 2015  |2 159  |o 10517