caa a22 4500 605535981 CHVBK 20210128100850.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10517-015-2980-z doi (NATIONALLICENCE)springer-10.1007/s10517-015-2980-z NMDA Receptors of A5 Area in the Regulation of Blood Pressure and Respiratory Activity during Hypoxia in Rats [Elektronische Daten] [V. Pyatin, V. Tatarnikov] In narcotized (40 mg/kg sodium ethaminal intraperitoneally) spontaneously breathing albino rats, experimental short-term hypoxia induced BP drop and increased phrenic nerve firing rate. Unilateral microinjection of a selective NMDA receptor blocker ketamine hydrochloride (50 nl; 4 mM) into A5 area did not affect BP and phrenic nerve fi ring rate. However, against the background of preliminary NMDA receptor blockage, hypoxia more markedly stimulated rhythmic activity of the respiratory center and hypotensive response. Unilateral microinjection of a selective blocker of non-NMDA receptors GAMS (50 nl; 4 mM) into A5 area did not change initial BP and phrenic nerve fi ring rate. The studied parameters in rats exposed to hypoxia after blockage of non-NMDA receptors in A5 area did not differ from the control levels. Thus, activity of the respiratory center and BP in rats during hypoxia is regulated by the structures in A5 area and NMDA glutamate receptors. Springer Science+Business Media New York, 2015 A5 area nationallicence NMDA receptors nationallicence hypoxia nationallicence phrenic nerve nationallicence blood pressure nationallicence Pyatin V. Department of Normal Physiology of the Samara State Medical University, Ministry of Health of the Russian Federation, Samara, Russia aut Tatarnikov V. Department of Normal Physiology of the Samara State Medical University, Ministry of Health of the Russian Federation, Samara, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 420-423 0007-4888 159:4<420 2015 159 10517 https://doi.org/10.1007/s10517-015-2980-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2980-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pyatin V. Department of Normal Physiology of the Samara State Medical University, Ministry of Health of the Russian Federation, Samara, Russia aut NATIONALLICENCE 700 1- Tatarnikov V. Department of Normal Physiology of the Samara State Medical University, Ministry of Health of the Russian Federation, Samara, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 420-423 0007-4888 159:4<420 2015 159 10517