Auditory Function in Immature Animals after Two Consecutive Courses of Ototoxic Antibiotics
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2979-5 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2979-5 | ||
| 245 | 0 | 0 | |a Auditory Function in Immature Animals after Two Consecutive Courses of Ototoxic Antibiotics |h [Elektronische Daten] |c [I. D'yakonova, O. Kamkina, Yu. Ishanova, I. Rakhmanova, D. Burmistrova] |
| 520 | 3 | |a In chronic experiments on immature rabbits receiving therapeutic courses of vancomycin, gentamicin, and consecutive administration of vancomicin and gentamicin by the scheme used in neonatology, hearing function was evaluated by the methods of auditory evoked potentials (auditory brainstem response, ABR) and distortion product otoacoustic emission (DPOAE). Comparison with the control group revealed ototoxic effects of all studied antibiotics that manifested in increased sound tolerance and more rapid shortening of latencies in 30-100 dB range. Higher thresholds were found only after gentamicin administration. Vancomycin administration significantly reduced the responses at 4 kHz. Subsequent gentamicin course did not potentiate this effect. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a gentamicin |2 nationallicence | |
| 690 | 7 | |a vancomycin |2 nationallicence | |
| 690 | 7 | |a immature rabbits |2 nationallicence | |
| 690 | 7 | |a auditory brainstem response (ABR) |2 nationallicence | |
| 690 | 7 | |a distortion product otoacoustic emission (DPOAE) |2 nationallicence | |
| 700 | 1 | |a D'yakonova |D I. |u Department of Physiology, Medico-Biological Faculty, Moscow, Russia |4 aut | |
| 700 | 1 | |a Kamkina |D O. |u Department of Pharmacology, Moscow, Russia |4 aut | |
| 700 | 1 | |a Ishanova |D Yu |u Research Laboratory of Clinical and Experimental Pediatric Otorhinolaryngology, Moscow, Russia |4 aut | |
| 700 | 1 | |a Rakhmanova |D I. |u Research Laboratory of Clinical and Experimental Pediatric Otorhinolaryngology, Moscow, Russia |4 aut | |
| 700 | 1 | |a Burmistrova |D D. |u Department of Pediatric Otorhinolaryngology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/4(2015-08-01), 415-419 |x 0007-4888 |q 159:4<415 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2979-5 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2979-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a D'yakonova |D I. |u Department of Physiology, Medico-Biological Faculty, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kamkina |D O. |u Department of Pharmacology, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ishanova |D Yu |u Research Laboratory of Clinical and Experimental Pediatric Otorhinolaryngology, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rakhmanova |D I. |u Research Laboratory of Clinical and Experimental Pediatric Otorhinolaryngology, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Burmistrova |D D. |u Department of Pediatric Otorhinolaryngology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/4(2015-08-01), 415-419 |x 0007-4888 |q 159:4<415 |1 2015 |2 159 |o 10517 | ||