caa a22 4500 605536031 CHVBK 20210128100850.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10517-015-2979-5 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2979-5 Auditory Function in Immature Animals after Two Consecutive Courses of Ototoxic Antibiotics [Elektronische Daten] [I. D'yakonova, O. Kamkina, Yu. Ishanova, I. Rakhmanova, D. Burmistrova] In chronic experiments on immature rabbits receiving therapeutic courses of vancomycin, gentamicin, and consecutive administration of vancomicin and gentamicin by the scheme used in neonatology, hearing function was evaluated by the methods of auditory evoked potentials (auditory brainstem response, ABR) and distortion product otoacoustic emission (DPOAE). Comparison with the control group revealed ototoxic effects of all studied antibiotics that manifested in increased sound tolerance and more rapid shortening of latencies in 30-100 dB range. Higher thresholds were found only after gentamicin administration. Vancomycin administration significantly reduced the responses at 4 kHz. Subsequent gentamicin course did not potentiate this effect. Springer Science+Business Media New York, 2015 gentamicin nationallicence vancomycin nationallicence immature rabbits nationallicence auditory brainstem response (ABR) nationallicence distortion product otoacoustic emission (DPOAE) nationallicence D'yakonova I. Department of Physiology, Medico-Biological Faculty, Moscow, Russia aut Kamkina O. Department of Pharmacology, Moscow, Russia aut Ishanova Yu Research Laboratory of Clinical and Experimental Pediatric Otorhinolaryngology, Moscow, Russia aut Rakhmanova I. Research Laboratory of Clinical and Experimental Pediatric Otorhinolaryngology, Moscow, Russia aut Burmistrova D. Department of Pediatric Otorhinolaryngology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 415-419 0007-4888 159:4<415 2015 159 10517 https://doi.org/10.1007/s10517-015-2979-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2979-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- D'yakonova I. Department of Physiology, Medico-Biological Faculty, Moscow, Russia aut NATIONALLICENCE 700 1- Kamkina O. Department of Pharmacology, Moscow, Russia aut NATIONALLICENCE 700 1- Ishanova Yu Research Laboratory of Clinical and Experimental Pediatric Otorhinolaryngology, Moscow, Russia aut NATIONALLICENCE 700 1- Rakhmanova I. Research Laboratory of Clinical and Experimental Pediatric Otorhinolaryngology, Moscow, Russia aut NATIONALLICENCE 700 1- Burmistrova D. Department of Pediatric Otorhinolaryngology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 415-419 0007-4888 159:4<415 2015 159 10517