Effect of Chronic Administration of Estradiol on Responsiveness of Isolated Systemic and Pulmonary Blood Vessels from Ovariectomized Wistar Rats with Hypoxic Pulmonary Hypertension
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 60553604X | ||
| 003 | CHVBK | ||
| 005 | 20210128100850.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20150801xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10517-015-2982-x |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2982-x | ||
| 245 | 0 | 0 | |a Effect of Chronic Administration of Estradiol on Responsiveness of Isolated Systemic and Pulmonary Blood Vessels from Ovariectomized Wistar Rats with Hypoxic Pulmonary Hypertension |h [Elektronische Daten] |c [M. Artem'eva, Yu. Kovaleva, O. Medvedev, N. Medvedeva] |
| 520 | 3 | |a The long-term (4 weeks) administration of estradiol (15 μg/kg/day) to ovariectomized female Wistar rats induced hypoxic pulmonary hypertension and significantly (p<0.05) diminished relaxation of perfused serotonin-preconstricted isolated vascular segments of the pulmonary artery in response to estradiol (10−6 M). At the same time, the isolated segments of systemic popliteal artery demonstrated a diminished response to serotonin and increased relaxation induced by acetylcholine (10−5 M) or estradiol (10−5 M) in comparison with preconstricted control vessels. Moderation of responsiveness to estradiol in pulmonary circulation can be one of the factors underlying the pro-hypertensive action of estradiol in female rats with hypoxic pulmonary hypertension. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a 17β-estradiol |2 nationallicence | |
| 690 | 7 | |a isolated arteries |2 nationallicence | |
| 690 | 7 | |a hypoxic pulmonary hypertension |2 nationallicence | |
| 690 | 7 | |a acetylcholine |2 nationallicence | |
| 690 | 7 | |a female rats |2 nationallicence | |
| 700 | 1 | |a Artem'eva |D M. |u Department of Human and Animal Physiology, Biological Faculty, Moscow, Russia |4 aut | |
| 700 | 1 | |a Kovaleva |D Yu |u Department of Pharmacology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Medvedev |D O. |u Department of Pharmacology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Medvedeva |D N. |u Department of Human and Animal Physiology, Biological Faculty, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/4(2015-08-01), 427-430 |x 0007-4888 |q 159:4<427 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2982-x |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2982-x |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Artem'eva |D M. |u Department of Human and Animal Physiology, Biological Faculty, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kovaleva |D Yu |u Department of Pharmacology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Medvedev |D O. |u Department of Pharmacology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Medvedeva |D N. |u Department of Human and Animal Physiology, Biological Faculty, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/4(2015-08-01), 427-430 |x 0007-4888 |q 159:4<427 |1 2015 |2 159 |o 10517 | ||