caa a22 4500 60553604X CHVBK 20210128100850.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10517-015-2982-x doi (NATIONALLICENCE)springer-10.1007/s10517-015-2982-x Effect of Chronic Administration of Estradiol on Responsiveness of Isolated Systemic and Pulmonary Blood Vessels from Ovariectomized Wistar Rats with Hypoxic Pulmonary Hypertension [Elektronische Daten] [M. Artem'eva, Yu. Kovaleva, O. Medvedev, N. Medvedeva] The long-term (4 weeks) administration of estradiol (15 μg/kg/day) to ovariectomized female Wistar rats induced hypoxic pulmonary hypertension and significantly (p<0.05) diminished relaxation of perfused serotonin-preconstricted isolated vascular segments of the pulmonary artery in response to estradiol (10−6 M). At the same time, the isolated segments of systemic popliteal artery demonstrated a diminished response to serotonin and increased relaxation induced by acetylcholine (10−5 M) or estradiol (10−5 M) in comparison with preconstricted control vessels. Moderation of responsiveness to estradiol in pulmonary circulation can be one of the factors underlying the pro-hypertensive action of estradiol in female rats with hypoxic pulmonary hypertension. Springer Science+Business Media New York, 2015 17β-estradiol nationallicence isolated arteries nationallicence hypoxic pulmonary hypertension nationallicence acetylcholine nationallicence female rats nationallicence Artem'eva M. Department of Human and Animal Physiology, Biological Faculty, Moscow, Russia aut Kovaleva Yu Department of Pharmacology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut Medvedev O. Department of Pharmacology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut Medvedeva N. Department of Human and Animal Physiology, Biological Faculty, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 427-430 0007-4888 159:4<427 2015 159 10517 https://doi.org/10.1007/s10517-015-2982-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2982-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Artem'eva M. Department of Human and Animal Physiology, Biological Faculty, Moscow, Russia aut NATIONALLICENCE 700 1- Kovaleva Yu Department of Pharmacology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 700 1- Medvedev O. Department of Pharmacology, Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 700 1- Medvedeva N. Department of Human and Animal Physiology, Biological Faculty, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 427-430 0007-4888 159:4<427 2015 159 10517