Intra-Arterial Administration of Multipotent Mesenchymal Stromal Cells Promotes Functional Recovery of the Brain After Traumatic Brain Injury
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3009-3 |2 doi |
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| 245 | 0 | 0 | |a Intra-Arterial Administration of Multipotent Mesenchymal Stromal Cells Promotes Functional Recovery of the Brain After Traumatic Brain Injury |h [Elektronische Daten] |c [D. Silachev, E. Plotnikov, V. Babenko, T. Danilina, L. Zorov, I. Pevzner, D. Zorov, G. Sukhikh] |
| 520 | 3 | |a We compared the efficiency of delivery of multipotent mesenchymal stem cells into the brain after their intravenous and intra-arterial injection. Analysis of the therapeutic effects of cells after experimental traumatic brain injury revealed improvement of the neurological status and motor functions of the damaged hemisphere, the effect being more pronounced after intraarterial injection of cells. Intra-arterial administration was followed by rapid infiltration of the cells into the brain tissue and their number considerably surpassed that after intravenous infusion. Targeted delivery of multipotent mesenchymal stromal cells into the brain after their injection into the carotid arteries substantially potentiated their neuroprotective effects in traumatic brain injury. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a traumatic brain injury |2 nationallicence | |
| 690 | 7 | |a stem cells |2 nationallicence | |
| 690 | 7 | |a migration |2 nationallicence | |
| 690 | 7 | |a sensorimotor deficit |2 nationallicence | |
| 700 | 1 | |a Silachev |D D. |u A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia |4 aut | |
| 700 | 1 | |a Plotnikov |D E. |u A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia |4 aut | |
| 700 | 1 | |a Babenko |D V. |u Faculty and Bioengineering and Bioinformatics, Moscow, Russia |4 aut | |
| 700 | 1 | |a Danilina |D T. |u Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Zorov |D L. |u International Laser Research Center, Moscow, Russia |4 aut | |
| 700 | 1 | |a Pevzner |D I. |u A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia |4 aut | |
| 700 | 1 | |a Zorov |D D. |u A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia |4 aut | |
| 700 | 1 | |a Sukhikh |D G. |u V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/4(2015-08-01), 528-533 |x 0007-4888 |q 159:4<528 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3009-3 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3009-3 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Silachev |D D. |u A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Plotnikov |D E. |u A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Babenko |D V. |u Faculty and Bioengineering and Bioinformatics, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Danilina |D T. |u Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zorov |D L. |u International Laser Research Center, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pevzner |D I. |u A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zorov |D D. |u A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sukhikh |D G. |u V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/4(2015-08-01), 528-533 |x 0007-4888 |q 159:4<528 |1 2015 |2 159 |o 10517 | ||