caa a22 4500 605536066 CHVBK 20210128100850.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10517-015-3009-3 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3009-3 Intra-Arterial Administration of Multipotent Mesenchymal Stromal Cells Promotes Functional Recovery of the Brain After Traumatic Brain Injury [Elektronische Daten] [D. Silachev, E. Plotnikov, V. Babenko, T. Danilina, L. Zorov, I. Pevzner, D. Zorov, G. Sukhikh] We compared the efficiency of delivery of multipotent mesenchymal stem cells into the brain after their intravenous and intra-arterial injection. Analysis of the therapeutic effects of cells after experimental traumatic brain injury revealed improvement of the neurological status and motor functions of the damaged hemisphere, the effect being more pronounced after intraarterial injection of cells. Intra-arterial administration was followed by rapid infiltration of the cells into the brain tissue and their number considerably surpassed that after intravenous infusion. Targeted delivery of multipotent mesenchymal stromal cells into the brain after their injection into the carotid arteries substantially potentiated their neuroprotective effects in traumatic brain injury. Springer Science+Business Media New York, 2015 traumatic brain injury nationallicence stem cells nationallicence migration nationallicence sensorimotor deficit nationallicence Silachev D. A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia aut Plotnikov E. A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia aut Babenko V. Faculty and Bioengineering and Bioinformatics, Moscow, Russia aut Danilina T. Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut Zorov L. International Laser Research Center, Moscow, Russia aut Pevzner I. A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia aut Zorov D. A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia aut Sukhikh G. V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 528-533 0007-4888 159:4<528 2015 159 10517 https://doi.org/10.1007/s10517-015-3009-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3009-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Silachev D. A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia aut NATIONALLICENCE 700 1- Plotnikov E. A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia aut NATIONALLICENCE 700 1- Babenko V. Faculty and Bioengineering and Bioinformatics, Moscow, Russia aut NATIONALLICENCE 700 1- Danilina T. Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 700 1- Zorov L. International Laser Research Center, Moscow, Russia aut NATIONALLICENCE 700 1- Pevzner I. A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia aut NATIONALLICENCE 700 1- Zorov D. A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia aut NATIONALLICENCE 700 1- Sukhikh G. V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 528-533 0007-4888 159:4<528 2015 159 10517