caa a22 4500 605536074 CHVBK 20210128100850.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10517-015-3002-x doi (NATIONALLICENCE)springer-10.1007/s10517-015-3002-x Evaluation of Biodistribution of Functionalized Magnetic Core/Carbon-Shell Nanoparticles in Systemic Method of Administration [Elektronische Daten] [B. Yushkov, O. Artashyan, S. Medvedeva, I. Byzov, M. Uimin, A. Ermakov, M. Bykova, I. Petrova] We studied new magnetic nanocomposites consisting of a core(Fe) and carbon-shell inert to biological media. Iron-carbon nanoparticles circulate in the bloodstream for several minutes and are primarily accumulated in the liver; less intensive accumulation was found in the spleen and minimum in the lungs, kidneys, and heart. Accumulation of nanoparticles in the liver leads to the development of destructive processes and is accompanied by activation of compensatory-adaptive mechanisms. In the liver and spleen, structural changes are mild and mainly relate to changes in the microvasculature. In 6 months, the total content of nanoparticles in all tissues decreased due to their elimination from the body and the structure of the organs returned to normal. Springer Science+Business Media New York, 2015 iron-carbon nanoparticles nationallicence biodistribution nationallicence Yushkov B. Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia aut Artashyan O. Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia aut Medvedeva S. Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia aut Byzov I. Institute of Metal Physics, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia aut Uimin M. Institute of Metal Physics, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia aut Ermakov A. Institute of Metal Physics, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia aut Bykova M. Ural Federal University n. a. First President of Russia B. N. Yeltsin, Ekaterinburg, Russia aut Petrova I. Ural Federal University n. a. First President of Russia B. N. Yeltsin, Ekaterinburg, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 498-501 0007-4888 159:4<498 2015 159 10517 https://doi.org/10.1007/s10517-015-3002-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3002-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yushkov B. Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia aut NATIONALLICENCE 700 1- Artashyan O. Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia aut NATIONALLICENCE 700 1- Medvedeva S. Institute of Immunology and Physiology, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia aut NATIONALLICENCE 700 1- Byzov I. Institute of Metal Physics, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia aut NATIONALLICENCE 700 1- Uimin M. Institute of Metal Physics, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia aut NATIONALLICENCE 700 1- Ermakov A. Institute of Metal Physics, Ural Division of Russian Academy of Sciences, Ekaterinburg, Russia aut NATIONALLICENCE 700 1- Bykova M. Ural Federal University n. a. First President of Russia B. N. Yeltsin, Ekaterinburg, Russia aut NATIONALLICENCE 700 1- Petrova I. Ural Federal University n. a. First President of Russia B. N. Yeltsin, Ekaterinburg, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/4(2015-08-01), 498-501 0007-4888 159:4<498 2015 159 10517