Role of cAMP- and IKK-2-Dependent Signaling Pathways in Functional Stimulation of Mesenchymal Progenitor Cells with Alkaloid Songorine

Verfasser / Beitragende:
[G. Zyuz'kov, V. Zhdanov, E. Udut, L. Miroshnichenko, A. Chaikovskii, E. Simanina, T. Polyakova, M. Minakova, V. Udut, T. Tolstikova, E. Shul'ts, L. Stavrova, Ya. Burmina, N. Suslov, A. Dygai]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 159/5(2015-09-01), 642-645
Format:
Artikel (online)
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024 7 0 |a 10.1007/s10517-015-3036-0  |2 doi 
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245 0 0 |a Role of cAMP- and IKK-2-Dependent Signaling Pathways in Functional Stimulation of Mesenchymal Progenitor Cells with Alkaloid Songorine  |h [Elektronische Daten]  |c [G. Zyuz'kov, V. Zhdanov, E. Udut, L. Miroshnichenko, A. Chaikovskii, E. Simanina, T. Polyakova, M. Minakova, V. Udut, T. Tolstikova, E. Shul'ts, L. Stavrova, Ya. Burmina, N. Suslov, A. Dygai] 
520 3 |a The role of cAMP- and IKK-2-dependent pathways in stimulation of the growth capacity of mesenchymal progenitor cells with alkaloid songorine was studied in vitro. Inhibitors of adenylate cyclase and IKK-2 were shown to abolish the increase in proliferative activity of progenitor cells. Moreover, blockade of the inhibitory kinase complex was accompanied by a decrease in the intensity of progenitor cell differentiation. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a cAMP  |2 nationallicence 
690 7 |a IKK  |2 nationallicence 
690 7 |a alkaloids  |2 nationallicence 
690 7 |a progenitor cells  |2 nationallicence 
690 7 |a regenerative medicine  |2 nationallicence 
700 1 |a Zyuz'kov  |D G.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
700 1 |a Zhdanov  |D V.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
700 1 |a Udut  |D E.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
700 1 |a Miroshnichenko  |D L.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
700 1 |a Chaikovskii  |D A.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
700 1 |a Simanina  |D E.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
700 1 |a Polyakova  |D T.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
700 1 |a Minakova  |D M.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
700 1 |a Udut  |D V.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
700 1 |a Tolstikova  |D T.  |u N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia  |4 aut 
700 1 |a Shul'ts  |D E.  |u N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia  |4 aut 
700 1 |a Stavrova  |D L.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
700 1 |a Burmina  |D Ya  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
700 1 |a Suslov  |D N.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
700 1 |a Dygai  |D A.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Zyuz'kov  |D G.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Zhdanov  |D V.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Udut  |D E.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Miroshnichenko  |D L.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Chaikovskii  |D A.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Simanina  |D E.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Polyakova  |D T.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Minakova  |D M.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Udut  |D V.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Tolstikova  |D T.  |u N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Shul'ts  |D E.  |u N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Stavrova  |D L.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Burmina  |D Ya  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Suslov  |D N.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Dygai  |D A.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/5(2015-09-01), 642-645  |x 0007-4888  |q 159:5<642  |1 2015  |2 159  |o 10517