caa a22 4500 605536120 CHVBK 20210128100851.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10517-015-3047-x doi (NATIONALLICENCE)springer-10.1007/s10517-015-3047-x Modulating Effect of Peptide Therapy on the Morphofunctional State of Bronchial Epithelium in Rats with Obstructive Lung Pathology [Elektronische Daten] [N. Kuzubova, E. Lebedeva, I. Dvorakovskaya, E. Surkova, I. Platonova, O. Titova] On the model of chronic obstructive pulmonary disease, the effect of therapy with low-molecular-weight peptides on restructuring and functional activity of bronchial epithelium for restoring the immune and barrier function of the lungs and prevention of inflammatory process progression was studied. Chronic obstructive pulmonary disease was modeled in rats by 60-day intermittent exposure to NO2. Administration of tetrapeptide Bronchogen for 1 month eliminates symptoms of remodeling of the bronchial epithelium and lung tissue typical of chronic obstructive pulmonary disease (goblet cell hyperplasia, squamous metaplasia, lymphocytic infiltration and emphysema, and restoration of ciliated cells). Enhanced production of secretory IgA, a local immunity marker, attested to normalization of functional activity of bronchial epithelium, while normalization of cell composition and profile of proinflammatory cytokines in the bronchoalveolar space reflected reduction of neutrophilic inflammation. Springer Science+Business Media New York, 2015 chronic obstructive pulmonary disease nationallicence bronchial epithelium nationallicence regulatory peptides, inflammation nationallicence Kuzubova N. Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia aut Lebedeva E. Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia aut Dvorakovskaya I. Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia aut Surkova E. Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia aut Platonova I. Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia aut Titova O. Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/5(2015-09-01), 685-688 0007-4888 159:5<685 2015 159 10517 https://doi.org/10.1007/s10517-015-3047-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3047-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kuzubova N. Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Lebedeva E. Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Dvorakovskaya I. Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Surkova E. Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Platonova I. Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Titova O. Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/5(2015-09-01), 685-688 0007-4888 159:5<685 2015 159 10517