Postsynaptic Potentiation in Mouse Motor Synapses Induced by ATP Accumulation in Synaptic Cleft
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3018-2 |2 doi |
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| 245 | 0 | 0 | |a Postsynaptic Potentiation in Mouse Motor Synapses Induced by ATP Accumulation in Synaptic Cleft |h [Elektronische Daten] |c [P. Bogacheva, O. Balezina] |
| 520 | 3 | |a In mouse motor synapses, a non-selective purinoceptor antagonist suramin increased the quantum content of endplate potentials (EPP) without changing the time course of synaptic potentials. An ectonucleotidase inhibitor ARL 67156 had no effect on the amplitude and quantum content of EPP and miniature endplate potentials (mEPP) evoked by single stimuli, but significantly prolonged their duration. Long-term high-frequency stimulation of the nerve in the presence of ARL 67156 persistently increased the amplitude and duration of EPP during the train of impulses, but did not change their quantum content. ATP-γ-S, a non-hydrolyzed ATP analogue, significantly increased the amplitudes and prolonged the rising and falling phases of EPP and mEPP. The ATP-induced postsynaptic potentiation in neuromuscular transmission can result from the increase in ATP content and its longer presence in the synaptic cleft. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a ATP |2 nationallicence | |
| 690 | 7 | |a motor synapse |2 nationallicence | |
| 690 | 7 | |a ectonucleotidase |2 nationallicence | |
| 690 | 7 | |a ATP-γ-S |2 nationallicence | |
| 690 | 7 | |a endplate potentials |2 nationallicence | |
| 700 | 1 | |a Bogacheva |D P. |u Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Balezina |D O. |u Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/5(2015-09-01), 583-587 |x 0007-4888 |q 159:5<583 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3018-2 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3018-2 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bogacheva |D P. |u Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Balezina |D O. |u Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/5(2015-09-01), 583-587 |x 0007-4888 |q 159:5<583 |1 2015 |2 159 |o 10517 | ||