caa a22 4500 605536139 CHVBK 20210128100851.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10517-015-3018-2 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3018-2 Postsynaptic Potentiation in Mouse Motor Synapses Induced by ATP Accumulation in Synaptic Cleft [Elektronische Daten] [P. Bogacheva, O. Balezina] In mouse motor synapses, a non-selective purinoceptor antagonist suramin increased the quantum content of endplate potentials (EPP) without changing the time course of synaptic potentials. An ectonucleotidase inhibitor ARL 67156 had no effect on the amplitude and quantum content of EPP and miniature endplate potentials (mEPP) evoked by single stimuli, but significantly prolonged their duration. Long-term high-frequency stimulation of the nerve in the presence of ARL 67156 persistently increased the amplitude and duration of EPP during the train of impulses, but did not change their quantum content. ATP-γ-S, a non-hydrolyzed ATP analogue, significantly increased the amplitudes and prolonged the rising and falling phases of EPP and mEPP. The ATP-induced postsynaptic potentiation in neuromuscular transmission can result from the increase in ATP content and its longer presence in the synaptic cleft. Springer Science+Business Media New York, 2015 ATP nationallicence motor synapse nationallicence ectonucleotidase nationallicence ATP-γ-S nationallicence endplate potentials nationallicence Bogacheva P. Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut Balezina O. Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/5(2015-09-01), 583-587 0007-4888 159:5<583 2015 159 10517 https://doi.org/10.1007/s10517-015-3018-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3018-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bogacheva P. Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 700 1- Balezina O. Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/5(2015-09-01), 583-587 0007-4888 159:5<583 2015 159 10517