Antioxidant Action of Apelin-12 Peptide and Its Structural Analog In Vitro
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3024-4 |2 doi |
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| 245 | 0 | 0 | |a Antioxidant Action of Apelin-12 Peptide and Its Structural Analog In Vitro |h [Elektronische Daten] |c [Y. Pelogeykina, G. Konovalova, O. Pisarenko, V. Lankin] |
| 520 | 3 | |a The effects of C-terminal fragment of natural peptide apelin-12 H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH (A12) and its structural analog H-(NαMe)Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Nle-Pro-Phe-OH (AI) on Cu2+-induced free radical oxidation of low-density lipoprotein in human blood plasma and activity of commercially available enzymes superoxide dismutase and catalase in a concentration range of 0.01-1 mM were examined. A12 and AI had no effect on superoxide dismutase and catalase activities during 24-h co-incubation with these enzymes at 4°C. When used in a concentration of 1 mM, A12 and AI decreased the maximum low-density lipoprotein oxidation rate by 51 and 47%, respectively, and lengthened the lag phase of low-density lipoprotein oxidation by 2.6 and 1.8 times, respectively, which confirmed their antioxidant potency. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a apelin-12 |2 nationallicence | |
| 690 | 7 | |a low-density lipoprotein free radical oxidation |2 nationallicence | |
| 690 | 7 | |a superoxide dismutase |2 nationallicence | |
| 690 | 7 | |a catalase |2 nationallicence | |
| 690 | 7 | |a myocardial ischemia/reperfusion |2 nationallicence | |
| 700 | 1 | |a Pelogeykina |D Y. |u Russian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 700 | 1 | |a Konovalova |D G. |u Russian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 700 | 1 | |a Pisarenko |D O. |u Russian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 700 | 1 | |a Lankin |D V. |u Russian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/5(2015-09-01), 604-606 |x 0007-4888 |q 159:5<604 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3024-4 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3024-4 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pelogeykina |D Y. |u Russian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Konovalova |D G. |u Russian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pisarenko |D O. |u Russian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lankin |D V. |u Russian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/5(2015-09-01), 604-606 |x 0007-4888 |q 159:5<604 |1 2015 |2 159 |o 10517 | ||