Evaluation of the Effect of Modified Bioflavonoid and Quercetin Dihydrate on Cytokine Secretion by Mitogen-Activated Mononuclear Cells
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3031-5 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-3031-5 | ||
| 245 | 0 | 0 | |a Evaluation of the Effect of Modified Bioflavonoid and Quercetin Dihydrate on Cytokine Secretion by Mitogen-Activated Mononuclear Cells |h [Elektronische Daten] |c [D. Albegova, O. Kamkina, S. Pavlova, Zh. Albegova, O. Laptev, I. Kozlov] |
| 520 | 3 | |a An experimental study revealed the effect on modified bioflavonoid on the inhibition of secretion of IFN-γ and IL-2 by ConA-stimulated mononuclear cells. These changes were accompanied by an increase in the secretion of IL-17 and IL-6. Our results suggest the differentiation of CD4+ T helper cells into Th1 and Th17 subpopulations. The reference drug quercetin dihydrate induced an insignificant change in the level of IL-2 and IL-6 and small increase in IFN-γ content. The content of IL-17 was shown to decrease above the detection limit. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a flavonoids |2 nationallicence | |
| 690 | 7 | |a cytokines |2 nationallicence | |
| 690 | 7 | |a mononuclear cells |2 nationallicence | |
| 700 | 1 | |a Albegova |D D. |u Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 700 | 1 | |a Kamkina |D O. |u Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 700 | 1 | |a Pavlova |D S. |u I. N. Ulyanov, Chuvash State University, Cheboksary, Russia |4 aut | |
| 700 | 1 | |a Albegova |D Zh |u North Ossetian State Medical Academy, Ministry of Health of the Russian Federation, Vladikavkaz, Russia |4 aut | |
| 700 | 1 | |a Laptev |D O. |u D. Rogachev Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia |4 aut | |
| 700 | 1 | |a Kozlov |D I. |u Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/5(2015-09-01), 626-628 |x 0007-4888 |q 159:5<626 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3031-5 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3031-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Albegova |D D. |u Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kamkina |D O. |u Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pavlova |D S. |u I. N. Ulyanov, Chuvash State University, Cheboksary, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Albegova |D Zh |u North Ossetian State Medical Academy, Ministry of Health of the Russian Federation, Vladikavkaz, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Laptev |D O. |u D. Rogachev Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kozlov |D I. |u Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/5(2015-09-01), 626-628 |x 0007-4888 |q 159:5<626 |1 2015 |2 159 |o 10517 | ||