caa a22 4500 605536163 CHVBK 20210128100851.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10517-015-3031-5 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3031-5 Evaluation of the Effect of Modified Bioflavonoid and Quercetin Dihydrate on Cytokine Secretion by Mitogen-Activated Mononuclear Cells [Elektronische Daten] [D. Albegova, O. Kamkina, S. Pavlova, Zh. Albegova, O. Laptev, I. Kozlov] An experimental study revealed the effect on modified bioflavonoid on the inhibition of secretion of IFN-γ and IL-2 by ConA-stimulated mononuclear cells. These changes were accompanied by an increase in the secretion of IL-17 and IL-6. Our results suggest the differentiation of CD4+ T helper cells into Th1 and Th17 subpopulations. The reference drug quercetin dihydrate induced an insignificant change in the level of IL-2 and IL-6 and small increase in IFN-γ content. The content of IL-17 was shown to decrease above the detection limit. Springer Science+Business Media New York, 2015 flavonoids nationallicence cytokines nationallicence mononuclear cells nationallicence Albegova D. Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia aut Kamkina O. Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia aut Pavlova S. I. N. Ulyanov, Chuvash State University, Cheboksary, Russia aut Albegova Zh North Ossetian State Medical Academy, Ministry of Health of the Russian Federation, Vladikavkaz, Russia aut Laptev O. D. Rogachev Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia aut Kozlov I. Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/5(2015-09-01), 626-628 0007-4888 159:5<626 2015 159 10517 https://doi.org/10.1007/s10517-015-3031-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3031-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Albegova D. Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Kamkina O. Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Pavlova S. I. N. Ulyanov, Chuvash State University, Cheboksary, Russia aut NATIONALLICENCE 700 1- Albegova Zh North Ossetian State Medical Academy, Ministry of Health of the Russian Federation, Vladikavkaz, Russia aut NATIONALLICENCE 700 1- Laptev O. D. Rogachev Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia aut NATIONALLICENCE 700 1- Kozlov I. Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/5(2015-09-01), 626-628 0007-4888 159:5<626 2015 159 10517