Effects of a New Benzimidazole Derivative on Generative Function of Female Rats

Verfasser / Beitragende:
[E. Kuzubova, L. Bugaeva, S. Sergeeva, V. Petrov, V. Kataev, I. Kharlamov, M. Mal'tsev]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 159/5(2015-09-01), 635-637
Format:
Artikel (online)
ID: 605536228
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024 7 0 |a 10.1007/s10517-015-3034-2  |2 doi 
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245 0 0 |a Effects of a New Benzimidazole Derivative on Generative Function of Female Rats  |h [Elektronische Daten]  |c [E. Kuzubova, L. Bugaeva, S. Sergeeva, V. Petrov, V. Kataev, I. Kharlamov, M. Mal'tsev] 
520 3 |a The effects of a new thietanylbenzimidazole derivative (K-134) on estrous cycles, conception processes, and sexual behavior of female rats were studied. Two-week oral treatment with K-134 in doses of 5 and 50 mg/kg shortened the estrus phase and prolonged proestrus. Changes in sexual behavior were presented by activation of receptive sexual motivations without affecting proceptive motivations. The pregnancy and fertility indexes in experimental females after mating with intact males increased and pre- and postimplantation embryonic death decreased. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a benzimidazole derivatives  |2 nationallicence 
690 7 |a actoprotectors  |2 nationallicence 
690 7 |a reproductivity  |2 nationallicence 
690 7 |a sexual behavior  |2 nationallicence 
690 7 |a estrous cycle  |2 nationallicence 
700 1 |a Kuzubova  |D E.  |u Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia  |4 aut 
700 1 |a Bugaeva  |D L.  |u Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia  |4 aut 
700 1 |a Sergeeva  |D S.  |u Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia  |4 aut 
700 1 |a Petrov  |D V.  |u Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia  |4 aut 
700 1 |a Kataev  |D V.  |u Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia  |4 aut 
700 1 |a Kharlamov  |D I.  |u Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia  |4 aut 
700 1 |a Mal'tsev  |D M.  |u Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia  |4 aut 
773 0 |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/5(2015-09-01), 635-637  |x 0007-4888  |q 159:5<635  |1 2015  |2 159  |o 10517 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Kuzubova  |D E.  |u Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Bugaeva  |D L.  |u Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Sergeeva  |D S.  |u Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Petrov  |D V.  |u Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Kataev  |D V.  |u Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Kharlamov  |D I.  |u Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Mal'tsev  |D M.  |u Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/5(2015-09-01), 635-637  |x 0007-4888  |q 159:5<635  |1 2015  |2 159  |o 10517