caa a22 4500 605536236 CHVBK 20210128100851.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10517-015-3022-6 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3022-6 Potential Role of Catecholamine Response to Acute Hypoxia in the Modification of the Effects of Radioprotectors [Elektronische Daten] [M. Vasin, I. Ushakov, V. Antipov] Involvement of hormonal response (catecholamine release) to acute hypoxia induced by radioprotectors in modification of their radioprotective properties was studied in experiments on outbred mature female albino mice, female albino rats, and dogs of both sexes. The response intensity was evaluated by the reduction of radioprotective and toxic properties of indralin (a α1-adrenoceptor agonist and a radioprotector). The radioprotective effect of indralin was measured using lethal doses of whole-body γ-irradiation (60Co) and its acute toxicity was assessed by LD50. It was found that repeated administration of indralin with 30-60-min intervals was followed by weakening of its radioprotective effect. Similar sensitization effect of indralin was observed after pretreatment with cystamine and epinephrine. Comparison of the severity of sensitization after administration of epinephrine and cystamine in the dose providing radioprotective effect showed that the potential aminothiol-induced release of catecholamines can provide optimal long-term radioprotective effect of epinephrine. Springer Science+Business Media New York, 2015 desensitization nationallicence cystamine nationallicence indralin nationallicence epinephrine nationallicence radioprotective effects nationallicence Vasin M. State Scientific Centre Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut Ushakov I. State Scientific Centre Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut Antipov V. State Scientific Centre Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/5(2015-09-01), 597-600 0007-4888 159:5<597 2015 159 10517 https://doi.org/10.1007/s10517-015-3022-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3022-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vasin M. State Scientific Centre Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Ushakov I. State Scientific Centre Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Antipov V. State Scientific Centre Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/5(2015-09-01), 597-600 0007-4888 159:5<597 2015 159 10517