Histological Changes in Pancreatic Islets of Animals with Experimental Diabetes Caused by Xanthurenic Acid under Condition of Suppression of Its Endogenous Synthesis
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3046-y |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-3046-y | ||
| 245 | 0 | 0 | |a Histological Changes in Pancreatic Islets of Animals with Experimental Diabetes Caused by Xanthurenic Acid under Condition of Suppression of Its Endogenous Synthesis |h [Elektronische Daten] |c [G. Meyramov, К.-D. Kohnert, А. Kikimbaeva, А. Аitkulov, Z. Кystaubaeva, G. Тykeshanova, O.-N. Dupont, Е. Laryushina, А. Меyramova, G. Zhuzbaeva, О. Коvalenko, A. Shaybek] |
| 520 | 3 | |a Long-term administration of pyridoxine to rats kept on a diabetogenic diet stimulating endogenous synthesis of xanthurenic acid resulted in minimal glycemia, less pronounced decrease in insulin content in β-cells, and more intensive excretion of xanthurenic acid with urine. Histological changes were observed in 23% pancreatic islets, whereas in rats not treated with pyridoxine, destruction and necrosis of 40-45% β-cells were found in 38% of studied islets. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a xanthurenic diabetes |2 nationallicence | |
| 690 | 7 | |a β-cells |2 nationallicence | |
| 690 | 7 | |a Zn 2+ ions |2 nationallicence | |
| 690 | 7 | |a pyridoxine |2 nationallicence | |
| 700 | 1 | |a Meyramov |D G. |u Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | |
| 700 | 1 | |a Kohnert |D К.-D |u Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | |
| 700 | 1 | |a Kikimbaeva |D А. |u Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | |
| 700 | 1 | |a Аitkulov |D А. |u Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | |
| 700 | 1 | |a Кystaubaeva |D Z. |u Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | |
| 700 | 1 | |a Тykeshanova |D G. |u E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | |
| 700 | 1 | |a Dupont |D O.-N |u Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | |
| 700 | 1 | |a Laryushina |D Е. |u Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | |
| 700 | 1 | |a Меyramova |D А. |u Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | |
| 700 | 1 | |a Zhuzbaeva |D G. |u E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | |
| 700 | 1 | |a Коvalenko |D О. |u E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | |
| 700 | 1 | |a Shaybek |D A. |u E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/5(2015-09-01), 680-684 |x 0007-4888 |q 159:5<680 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3046-y |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3046-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Meyramov |D G. |u Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kohnert |D К.-D |u Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kikimbaeva |D А. |u Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Аitkulov |D А. |u Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Кystaubaeva |D Z. |u Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Тykeshanova |D G. |u E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dupont |D O.-N |u Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Laryushina |D Е. |u Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Меyramova |D А. |u Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhuzbaeva |D G. |u E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Коvalenko |D О. |u E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shaybek |D A. |u E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/5(2015-09-01), 680-684 |x 0007-4888 |q 159:5<680 |1 2015 |2 159 |o 10517 | ||