caa a22 4500 605536287 CHVBK 20210128100851.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10517-015-3045-z doi (NATIONALLICENCE)springer-10.1007/s10517-015-3045-z Ultrastructural Changes in the Intestine of Suckling Rabbits Infected with Cholerogenic and Non-Cholerogenic nonO1/nonO139 Vibrio cholerae Strains [Elektronische Daten] [E. Monakhova, G. Fedorenko, A. Mazrukho, E. Bardakhch'yan] We performed an electron microscopic study of the small intestine of suckling rabbits infected with cholerogenic and non-cholerogenic strains nonO1/nonO139 Vibrio cholerae. Cholerogenic strain induced mostly hydropic degeneration of the epithelium typical of cholera toxin effect, while non-cholerogenic strain induced the formation of lacunae along the borders of adjacent epithelial cells typical of hemagglutinin/protease effect. In both cases, reduction of microvilli, destruction of intracellular organelles, two types of mitochondrial reaction (condensation and swelling with destruction of cristae), appearance of myelin figures, defects in the capillary walls, and activation of pinocytosis were observed. These data confirm our previous assumption on interchangeability of different pathogenic factors of Vibrio cholerae, including nonO1/nonO139 strains. Springer Science+Business Media New York, 2015 Vibrio cholerae nationallicence pathogenic factors nationallicence ultrastructure nationallicence Monakhova E. Rostov-on-Don Research Institute for Plague Control, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Rostov-on-Don, Russia aut Fedorenko G. Institute of Arid Zones, Southern Research Center of the Russian Academy of Sciences, Rostov-on-Don, Russia aut Mazrukho A. Rostov-on-Don Research Institute for Plague Control, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Rostov-on-Don, Russia aut Bardakhch'yan E. Rostov-on-Don Research Institute for Plague Control, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Rostov-on-Don, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/5(2015-09-01), 675-679 0007-4888 159:5<675 2015 159 10517 https://doi.org/10.1007/s10517-015-3045-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3045-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Monakhova E. Rostov-on-Don Research Institute for Plague Control, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Rostov-on-Don, Russia aut NATIONALLICENCE 700 1- Fedorenko G. Institute of Arid Zones, Southern Research Center of the Russian Academy of Sciences, Rostov-on-Don, Russia aut NATIONALLICENCE 700 1- Mazrukho A. Rostov-on-Don Research Institute for Plague Control, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Rostov-on-Don, Russia aut NATIONALLICENCE 700 1- Bardakhch'yan E. Rostov-on-Don Research Institute for Plague Control, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Rostov-on-Don, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/5(2015-09-01), 675-679 0007-4888 159:5<675 2015 159 10517