Expression of Glutamate and Glutamine Transporter Proteins in Neurovascular Unit Cells In Vitro
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3027-1 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-3027-1 | ||
| 245 | 0 | 0 | |a Expression of Glutamate and Glutamine Transporter Proteins in Neurovascular Unit Cells In Vitro |h [Elektronische Daten] |c [A. Morgun, N. Kuvacheva, E. Khilazheva, T. Taranushenko, A. Salmina] |
| 520 | 3 | |a Glutamine transporter protein SLC1A5 and glutamate transporter protein EAAT2 responsible for cell-cell communication and energetic coupling were studied using in vitro model of multicellular neurovascular unit consisting of astrocytes, neurons, and endotheliocytes under standard conditions and during chemical hypoxia in vitro. Hypoxic damage to the neurovascular unit cells increased the number of SLC1A5-expressing cells and reduced the number of EAAT2-expressing astrocytes. Metabolic uncoupling in the neurovascular unit cells under hypoxic conditions resulted from abnormal expression of glutamine and glutamate transporter proteins, which is indicative of impaired glutamine and glutamate transport. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a neurovascular unit |2 nationallicence | |
| 690 | 7 | |a cell-cell interactions |2 nationallicence | |
| 690 | 7 | |a transport proteins |2 nationallicence | |
| 690 | 7 | |a hypoxia |2 nationallicence | |
| 700 | 1 | |a Morgun |D A. |u V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia |4 aut | |
| 700 | 1 | |a Kuvacheva |D N. |u V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia |4 aut | |
| 700 | 1 | |a Khilazheva |D E. |u V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia |4 aut | |
| 700 | 1 | |a Taranushenko |D T. |u V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia |4 aut | |
| 700 | 1 | |a Salmina |D A. |u V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/5(2015-09-01), 614-616 |x 0007-4888 |q 159:5<614 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3027-1 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3027-1 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Morgun |D A. |u V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kuvacheva |D N. |u V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Khilazheva |D E. |u V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Taranushenko |D T. |u V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Salmina |D A. |u V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/5(2015-09-01), 614-616 |x 0007-4888 |q 159:5<614 |1 2015 |2 159 |o 10517 | ||