caa a22 4500 605536325 CHVBK 20210128100852.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10517-015-3028-0 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3028-0 Effect of Sulfated Polysaccharides from Brown Algae on Apoptosis of Human Peripheral Blood Lymphocytes [Elektronische Daten] [A. Gazha, T. Zaporozhets, T. Kuznetsova, T. Zvyaguintseva, N. Besednova] We studied the influence of fucoidans from brown algae Fucus evanescens, Laminaria cichorioides and Laminaria japonica on apoptosis of human peripheral blood lymphocytes. It was demonstrated that fucoidans induced lymphocyte apoptosis, increased the proportion of cells with low mitochondrial transmembrane potential, and inhibit expression of Bcl-xL gene in blood lymphocytes. These findings suggest that lymphocyte apoptosis induced by the analyzed sulfated polysaccharides is mediated by mitochondrial pathway. Springer Science+Business Media New York, 2015 apoptosis nationallicence periperal blood lymphocytes nationallicence mitochondrial membrane potential nationallicence fucoidan nationallicence Gazha A. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Sciences, Vladivostok, Russia aut Zaporozhets T. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Sciences, Vladivostok, Russia aut Kuznetsova T. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Sciences, Vladivostok, Russia aut Zvyaguintseva T. G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia aut Besednova N. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Sciences, Vladivostok, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/5(2015-09-01), 617-619 0007-4888 159:5<617 2015 159 10517 https://doi.org/10.1007/s10517-015-3028-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3028-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gazha A. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Sciences, Vladivostok, Russia aut NATIONALLICENCE 700 1- Zaporozhets T. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Sciences, Vladivostok, Russia aut NATIONALLICENCE 700 1- Kuznetsova T. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Sciences, Vladivostok, Russia aut NATIONALLICENCE 700 1- Zvyaguintseva T. G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia aut NATIONALLICENCE 700 1- Besednova N. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Sciences, Vladivostok, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/5(2015-09-01), 617-619 0007-4888 159:5<617 2015 159 10517