Brattleboro Rats as the Model of Blood Hyperviscosity Syndrome for Testing Substances with Hemorheological Activity
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3048-9 |2 doi |
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| 245 | 0 | 0 | |a Brattleboro Rats as the Model of Blood Hyperviscosity Syndrome for Testing Substances with Hemorheological Activity |h [Elektronische Daten] |c [M. Plotnikov, A. Vasil'ev, O. Aliev, L. Zibareva] |
| 520 | 3 | |a Hyperviscosity syndrome was described in Brattleboro rats. The aim of this study was to investigate the possibility of Brattleboro rats using, as a test system for the study of agents with hemorheological activity. Under conditions of this model of high blood viscosity syndrome in Brattleboro rats, Lychnis chalcedonica L. extract (150 mg/kg) administered intragastrically for 10 days exhibited hemorheological activity by modulating macro- (plasma viscosity, fibrinogen concentration) and microrheological (erythrocyte aggregation and deformability parameters. Hence, Brattleboro rats are an adequate model of hyperviscosity syndrome that can be used for search and testing of substances with hemorheological activity. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a hereditary hypothalamic diabetes insipidus |2 nationallicence | |
| 690 | 7 | |a Brattleboro rats |2 nationallicence | |
| 690 | 7 | |a Lychnis chalcedonica extract |2 nationallicence | |
| 690 | 7 | |a high blood viscosity syndrome |2 nationallicence | |
| 690 | 7 | |a erythrocyte aggregation and deformability |2 nationallicence | |
| 700 | 1 | |a Plotnikov |D M. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Vasil'ev |D A. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Aliev |D O. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Zibareva |D L. |u National Research Tomsk State University, Tomsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/5(2015-09-01), 689-691 |x 0007-4888 |q 159:5<689 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3048-9 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3048-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Plotnikov |D M. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Vasil'ev |D A. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Aliev |D O. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zibareva |D L. |u National Research Tomsk State University, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/5(2015-09-01), 689-691 |x 0007-4888 |q 159:5<689 |1 2015 |2 159 |o 10517 | ||